{"id":8332,"date":"2023-01-31T08:20:55","date_gmt":"2023-01-30T23:20:55","guid":{"rendered":"https:\/\/rakuten-med.com\/jp\/?post_type=press_releases&#038;p=8332"},"modified":"2023-02-08T14:45:16","modified_gmt":"2023-02-08T05:45:16","slug":"%e6%a5%bd%e5%a4%a9%e3%83%a1%e3%83%87%e3%82%a3%e3%82%ab%e3%83%ab%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e6%8a%97%e4%bd%93-%e5%85%89%e6%84%9f%e5%8f%97%e6%80%a7%e7%89%a9%e8%b3%aa%e8%a4%87%e5%90%88%e4%bd%93","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2023\/01\/31\/8332\/","title":{"rendered":"\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306e\u65b0\u305f\u306a\u6297\u4f53-\u5149\u611f\u53d7\u6027\u7269\u8cea\u8907\u5408\u4f53\u3067\u3042\u308bRM-0256\u3092\u542b\u3080\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306e\u9032\u6357\u3001\u65e5\u672c\u5e02\u5834\u3067\u306e\u6210\u9577\u3001\u4eca\u5f8c\u6570\u5e74\u306e\u91cd\u8981\u306a\u30de\u30a4\u30eb\u30b9\u30c8\u30f3\u306a\u3069\u306e\u6700\u65b0\u60c5\u5831\u306b\u3064\u3044\u3066\u3001\u7b2c41\u56deJ.P.\u30e2\u30eb\u30ac\u30f3\u30fb\u30d8\u30eb\u30b9\u30b1\u30a2\u30fb\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u3067\u767a\u8868"},"content":{"rendered":"<div 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href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9496661\/\" target=\"_blank\" rel=\"noopener\">Quality-of-Life Evaluation of Patients with Unresectable Locally Advanced or Locally Recurrent Head and Neck Carcinoma Treated with Head and Neck Photoimmunotherap<\/a>y\u300d<sup>4<\/sup>\u3084\u300c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9688155\/\" target=\"_blank\" rel=\"noopener\">Near-Infrared Photoimmunotherapy for Oropharyngeal Cancer<\/a>\u300d<sup>5<\/sup>\u3067\u306f\u3001\u672c\u533b\u85ac\u54c1\u30fb\u533b\u7642\u6a5f\u5668\u30ec\u30fc\u30b6\u88c5\u7f6e\u3092\u7528\u3044\u305f\u300c\u982d\u9838\u90e8\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u300d\u304cQuality of Life\uff08QOL\uff09\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306a\u304f\u826f\u597d\u306a\u75c5\u72b6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3092\u9054\u6210\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u65e5\u672c\u3067\u84c4\u7a4d\u3055\u308c\u3064\u3064\u3042\u308b\u30c7\u30fc\u30bf\u3084\u77e5\u898b\u3092\u57fa\u306b\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u30b0\u30ed\u30fc\u30d0\u30eb\u5c55\u958b\u3092\u7a4d\u6975\u7684\u306b\u9032\u3081\u3066\u3044\u307e\u3059\u30022022\u5e74\u306b\u5b50\u4f1a\u793e\u3092\u8a2d\u7acb\u3057\u305f\u30a4\u30f3\u30c9\u306b\u3064\u3044\u3066\u306f\u3001ASP-1929\u3092\u7528\u3044\u305f\u5c40\u6240\u518d\u767a\u982d\u9838\u90e8\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u306b\u5bfe\u3059\u308b\u56fd\u969b\u5171\u540c\u7b2cIII\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08ASP-1929-301\u8a66\u9a13\uff0fClinicalTrials.gov Identifier: <a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03769506\" target=\"_blank\" rel=\"noopener\">NCT03769506<\/a>\uff09\u3092\u540c\u56fd\u3067\u3082\u5b9f\u65bd\u3067\u304d\u308b\u3088\u3046\u65bd\u8a2d\u7d44\u307f\u5165\u308c\u306e\u6e96\u5099\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002ASP-1929\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u304c\u826f\u597d\u3067\u3042\u308c\u3070\u3001\u65e9\u3051\u308c\u30702025\u5e74\u306b\u3082\u7c73\u56fd\u3001\u53f0\u6e7e\u3001\u30a4\u30f3\u30c9\u306a\u3069\u3067\u627f\u8a8d\u3092\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4ed6\u3001RM-1995\u3084RM-0256\u3092\u7528\u3044\u305f\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u958b\u59cb\u3001ASP-1929\u3092\u7528\u3044\u305f\u8907\u6570\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u9032\u6357\u306a\u3069\u3001\u591a\u304f\u306e\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u304c\u4eca\u5f8c\u6570\u5e74\u4ee5\u5185\u306b\u91cd\u8981\u306a\u30de\u30a4\u30eb\u30b9\u30c8\u30f3\u3092\u8fce\u3048\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n<p>\u300c\u3082\u3057\u72d9\u3063\u305f\u7d30\u80de\u3060\u3051\u3092\u53d6\u308a\u9664\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u3057\u305f\u3089\u3001\u3069\u3093\u306a\u672a\u6765\u304c\u62d3\u3051\u308b\u3067\u3057\u3087\u3046\uff1f\u300d\u8b1b\u6f14\u3067\u3053\u3046\u5207\u308a\u51fa\u3057\u305f\u4e09\u6728\u8c37\u306f\u3001\u300c\u65e2\u5b58\u306e\u6cbb\u7642\u6cd5\u3068\u306f\u5168\u304f\u7570\u306a\u308b\u3053\u306e\u6cbb\u7642\u6cd5\u306b\u79c1\u304c\u51fa\u4f1a\u3063\u3066\u304b\u308910\u5e74\u3001\u51c4\u307e\u3058\u3044\u52e2\u3044\u3067\u6280\u8853\u958b\u767a\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u304c\u63cf\u304f\u672a\u6765\u306f\u3001\u5c40\u6240\u6cbb\u7642\u3068\u3057\u3066\u306e\u30dd\u30b8\u30b7\u30e7\u30f3\u78ba\u7acb\u306b\u7559\u307e\u308a\u307e\u305b\u3093\u3002\u65e2\u5b58\u306e\u6cbb\u7642\u6cd5\u304c100\u5e74\u4ee5\u4e0a\u304b\u3051\u3066\u78ba\u7acb\u3057\u305f\u6a19\u6e96\u6cbb\u7642\u306e\u30dd\u30b8\u30b7\u30e7\u30f3\u3084\u3055\u3089\u306a\u308b\u9032\u5316\u3078\u306e\u9053\u7b4b\u3092\u3001\u5f53\u793e\u306f\u305a\u3063\u3068\u77ed\u3044\u30bf\u30a4\u30e0\u30e9\u30a4\u30f3\u3067\u5b9f\u73fe\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u300d\u3068\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8a9e\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>JPM2023\u3067\u306e\u4e09\u6728\u8c37\u306e\u8b1b\u6f14\u8cc7\u6599\u3068\u97f3\u58f0\uff08\u3044\u305a\u308c\u3082\u82f1\u8a9e\u306e\u307f\uff09\u306f\u4ee5\u4e0b\u306e\u30ea\u30f3\u30af\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3044\u305f\u3060\u3051\u307e\u3059\u3002<br \/>\n\u8b1b\u6f14\u8cc7\u6599: <a href=\"https:\/\/rakuten-med.com\/jp\/wp-content\/uploads\/sites\/8\/2023\/01\/Slides_JPM2023_Rakuten-Medical.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/rakuten-med.com\/jp\/wp-content\/uploads\/sites\/8\/2023\/01\/Slides_JPM2023_Rakuten-Medical.pdf<\/a><br \/>\n\u97f3\u58f0: <a href=\"https:\/\/rakuten-med.com\/jp\/wp-content\/uploads\/sites\/8\/2023\/01\/Audio-Recording_JPM2023_Rakuten-Medical-1.mp3\" target=\"_blank\" rel=\"noopener\">https:\/\/rakuten-med.com\/jp\/wp-content\/uploads\/sites\/8\/2023\/01\/Audio-Recording_JPM2023_Rakuten-Medical-1.mp3<\/a><\/p>\n<p>\uff08\u6ce8\uff09 \u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u57fa\u306b\u3057\u305f\u6cbb\u7642\u6cd5\u306f\u3001\u73fe\u6642\u70b9\u3067\u306f\u3001\u65e5\u672c\u4ee5\u5916\u306e\u56fd\u3067\u306f\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<div style=\"font-size: 0.8em\">1. <span class=\"NormalTextRun SpellingErrorV2Themed SCXW61599306 BCX0\" data-ccp-charstyle=\"normaltextrun\" data-ccp-charstyle-defn=\"{&quot;ObjectId&quot;:&quot;6705252b-c637-47e4-9cca-a5a40bb82990|105&quot;,&quot;ClassId&quot;:1073872969,&quot;Properties&quot;:[469775450,&quot;normaltextrun&quot;,201340122,&quot;1&quot;,134233614,&quot;true&quot;,469778129,&quot;normaltextrun&quot;,335572020,&quot;1&quot;,469778324,&quot;Default Paragraph Font&quot;]}\">Chunwan<\/span><span class=\"NormalTextRun SCXW61599306 BCX0\" data-ccp-charstyle=\"normaltextrun\"> Lu, Priscilla S. Redd, Jeffrey R. Lee, Natasha Savage &amp; <\/span><span class=\"NormalTextRun SCXW61599306 BCX0\" data-ccp-charstyle=\"normaltextrun\">Kebin<\/span><span class=\"NormalTextRun SCXW61599306 BCX0\" data-ccp-charstyle=\"normaltextrun\"> Liu (2016) The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW61599306 BCX0\" data-ccp-charstyle=\"normaltextrun\">OncoImmunology<\/span><span class=\"NormalTextRun SCXW61599306 BCX0\" data-ccp-charstyle=\"normaltextrun\">, 5:12, DOI:<\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/2162402X.2016.1247135\" target=\"_blank\" rel=\"noopener\">10.1080\/2162402X.2016.1247135<\/a><br \/>\n2. Kythreotou A, Siddique A, Mauri FA, et alPD-L1Journal of Clinical Pathology 2018;71:189-194. <a href=\"https:\/\/jcp.bmj.com\/content\/71\/3\/189\" target=\"_blank\" rel=\"noopener\">https:\/\/jcp.bmj.com\/content\/71\/3\/189<\/a><br \/>\n3. Shklovskaya, E.; Rizos, H. Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy. Int. J. Mol. Sci. 2020, 21, 7139. <a href=\"https:\/\/doi.org\/10.3390\/ijms21197139\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/ijms21197139<\/a><br \/>\n4. Isaku Okamoto et al. Cancers (Basel). 2022 Sep; 14(18): 4413. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9496661\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9496661\/<\/a><br \/>\n5. Daisuke Nishikawa et al. Cancers (Basel). 2022 Nov; 14(22): 5662. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9688155\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9688155\/<\/a><\/div>\n<p>&nbsp;<\/p>\n<p><strong>\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\u306b\u3064\u3044\u3066<\/strong><br \/>\n\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\u306f\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u547c\u3076\u6280\u8853\u57fa\u76e4\u3092\u57fa\u306b\u3001\u85ac\u5264\u3068\u5149\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3001\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u884c\u3046\u30b0\u30ed\u30fc\u30d0\u30eb\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u57fa\u306b\u958b\u767a\u3055\u308c\u305f\u533b\u85ac\u54c1\u30fb\u533b\u7642\u6a5f\u5668\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306e\u901f\u3084\u304b\u3001\u304b\u3064\u9078\u629e\u7684\u306a\u58ca\u6b7b\u3092\u3082\u305f\u3089\u3059\u30c7\u30fc\u30bf\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<span class=\"TextRun SCXW218726172 BCX0\" lang=\"JA-JP\" xml:lang=\"JA-JP\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW218726172 BCX0\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\u306f\u3001<\/span><\/span><span class=\"TrackChangeTextInsertion TrackedChange SCXW218726172 BCX0\"><span class=\"TextRun SCXW218726172 BCX0\" lang=\"JA-JP\" xml:lang=\"JA-JP\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW218726172 BCX0\">\u4e16\u754c\u4e2d\u306e\u4e00\u4eba\u3067\u3082\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306b\u3001\u4e00\u65e5\u3067\u3082\u65e9\u304f\u3001\u79c1\u305f\u3061\u306e\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u304a\u5c4a\u3051\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u300c\u304c\u3093\u514b\u670d\u3002\u300d\u3068\u3044\u3046\u30df\u30c3\u30b7\u30e7\u30f3\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/span><\/span>\u7c73\u56fd\u306b\u3001\u672c\u793e\u3068\u7814\u7a76\u958b\u767a\u62e0\u70b9\u3092\u69cb\u3048\u3001\u65e5\u672c\u3001\u30aa\u30e9\u30f3\u30c0\u3001\u53f0\u6e7e\u3001\u30a4\u30f3\u30c9\u3001\u30b9\u30a4\u30b9\u306e\u4e16\u754c6\u30ab\u56fd\u3092\u62e0\u70b9\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u682a\u5f0f\u4f1a\u793e\u306f\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\uff08\u7c73\u56fd\u6cd5\u4eba\uff09\u306e\u65e5\u672c\u6cd5\u4eba\u3067\u3059\u3002\u8a73\u3057\u304f\u306f\u3001<a href=\"https:\/\/rakuten-med.com\/jp\/\" rel=\"noopener\">https:\/\/rakuten-med.com\/jp\/<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u3064\u3044\u3066<\/strong><br 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2 \u6bb5\u968e\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u85ac\u5264\u306f\u3001\u5149\u611f\u53d7\u6027\u7269\u8cea (\u5149\u306b\u53cd\u5fdc\u3059\u308b\u7269\u8cea) \u3068\u3001\u30ad\u30e3\u30ea\u30a2 (\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3059\u308b\u6210\u5206) 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\/>\n\u3053\u306e\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306b\u542b\u307e\u308c\u308b\u8868\u73fe\u306f\u30011995\u5e74\u7c73\u56fd\u6c11\u4e8b\u8a3c\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\uff08Private Securities Litigation Reform Act of 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