{"id":8422,"date":"2023-07-12T13:30:22","date_gmt":"2023-07-12T04:30:22","guid":{"rendered":"https:\/\/rakuten-med.com\/jp\/?post_type=press_releases&#038;p=8422"},"modified":"2023-07-12T13:30:53","modified_gmt":"2023-07-12T04:30:53","slug":"%e6%a5%bd%e5%a4%a9%e3%83%a1%e3%83%87%e3%82%a3%e3%82%ab%e3%83%ab%e3%80%81%e5%86%8d%e7%99%ba%e5%8f%88%e3%81%af%e8%bb%a2%e7%a7%bb%e6%80%a7%e9%a0%ad%e9%a0%b8%e9%83%a8%e3%81%8c%e3%82%93%e3%81%ab%e5%af%be","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2023\/07\/12\/8422\/","title":{"rendered":"\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u3001\u518d\u767a\u53c8\u306f\u8ee2\u79fb\u6027\u982d\u9838\u90e8\u304c\u3093\u306b\u5bfe\u3059\u308bASP-1929\u3092\u7528\u3044\u305f\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u3068\u6297PD-1\u6297\u4f53\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3051\u308b\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u6709\u671b\u306a\u65e9\u671f\u8a55\u4fa1\u30c7\u30fc\u30bf\u3092\u7c73\u56fd\u982d\u9838\u90e8\u5b66\u4f1a\u3067\u767a\u8868"},"content":{"rendered":"<div id=\"pl-8422\"  class=\"panel-layout\" ><div id=\"pg-8422-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8422-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8422-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>- \u5fcd\u5bb9\u6027\u306f\u6982\u306d\u826f\u597d\u3067\u3042\u308a\u3001\u751f\u5b58\u7387\u306f18\u30f5\u6708\u6642\u70b9\u306753.5% <sup>1)<\/sup><\/strong><br \/>\n<strong>- \u518d\u767a\u982d\u9838\u90e8\u304c\u3093\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u9769\u65b0\u7684\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u3068\u306a\u308b\u53ef\u80fd\u6027<\/strong><\/p>\n<p>\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\uff08\u672c\u793e\uff1a\u7c73\u56fd \u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5dde \u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\uff0f\u4ee5\u4e0b\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\uff09\u306f\u30012023\u5e747\u670810\u65e5\u3001\u30ab\u30ca\u30c0\u30fb\u30e2\u30f3\u30c8\u30ea\u30aa\u30fc\u30eb\u3067\u958b\u50ac\u3055\u308c\u305f\u7c73\u56fd\u982d\u9838\u90e8\u5b66\u4f1a\uff08American Head and Neck Society\uff09\u306e11<sup>th<\/sup> International Conference on Head and Neck Cancer\uff08\u4ee5\u4e0b\u3001AHNS 2023\uff09\u306b\u304a\u3044\u3066\u3001ASP-1929\u3092\u7528\u3044\u305f\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u3068\u6297PD-1\u6297\u4f53\u306e\u4f75\u7528\u7642\u6cd5\u306b\u95a2\u3059\u308b\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3059\u308b\u975e\u76f2\u691c\u7b2c\u2160b \/\u2161\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08ASP-1929-181\u8a66\u9a13\uff0fClinicalTrials.gov Identifier\uff1a<a href=\"https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT04305795\" target=\"_blank\" rel=\"noopener\">NCT04305795<\/a>\uff09\u306e\u65e9\u671f\u8a55\u4fa1\u30c7\u30fc\u30bf\u304c\u767a\u8868\u3055\u308c\u305f\u3053\u3068\u3092\u304a\u77e5\u3089\u305b\u3057\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u767a\u8868\u3067\u306f\u3001ASP-1929-181\u8a66\u9a13\u306b\u767b\u9332\u3055\u308c\u305f\u518d\u767a\u53c8\u306f\u8ee2\u79fb\u6027\u306e\u982d\u9838\u90e8\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u306e\u60a3\u8005\u3055\u309319\u4f8b\u306e\u65e9\u671f\u8a55\u4fa1\u30c7\u30fc\u30bf\u306b\u304a\u3044\u3066\u3001\u672c\u4f75\u7528\u7642\u6cd5\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u306b\u95a2\u3059\u308b\u6709\u671b\u306a\u7d50\u679c\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><span style=\"text-decoration: underline\"><strong>AHNS2023\u3067\u306e\u4e3b\u306a\u767a\u8868\u5185\u5bb9<\/strong><\/span><\/p>\n<p><strong>\u6f14\u984c\uff1aSafety and efficacy findings from a phase 1b\/2 open-label study of a novel combination of ASP-1929 photoimmunotherapy with anti-PD-1 therapy in EGFR-expressing advanced head and neck squamous cell carcinoma<\/strong>\uff08\u6284\u9332\u756a\u53f7\uff1aS252\uff09<\/p>\n<p>- \u5ba2\u89b3\u7684\u594f\u52b9\u7387\uff08Objective Response Rate\uff1aORR\uff09\u306f29.4\uff05\uff085\u4f8b\u300195\uff05\u4fe1\u983c\u533a\u9593\uff1a10.3-56.0\uff09\u3001\u3046\u306117.6\uff05\uff083\u4f8b\uff09\u304c\u5b8c\u5168\u594f\u52b9\uff08Complete Responses\uff1aCR\uff09\u300111.8\uff05\uff082\u4f8b\uff09\u304c\u90e8\u5206\u594f\u52b9\uff08Partial Responses\uff1aPR\uff09\u3067\u3042\u3063\u305f<sup>2)<\/sup><br \/>\n- \u751f\u5b58\u7387\uff08Overall Survival\uff1aOS\uff09\u306f18\u30f5\u6708\u6642\u70b9\u306753.5%\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff1a18.5-79.3\uff09\u3067\u3042\u3063\u305f<sup>1)2)<\/sup><br \/>\n- \u6709\u5bb3\u4e8b\u8c61\u306f\u7ba1\u7406\u53ef\u80fd\u3067\u6982\u306d\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u793a\u3057\u305f<br \/>\n- \u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u6709\u671b\u306a\u65e9\u671f\u8a55\u4fa1\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u305f\u3053\u3068\u304b\u3089\u3001\u3055\u3089\u306a\u308b\u81e8\u5e8a\u8a66\u9a13\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u4e88\u5099\u7684\u767a\u898b\u3092\u691c\u8a3c\u3059\u308b\u610f\u7fa9\u304c\u3042\u308b\u3068\u8003\u3048\u308b<\/p>\n<p><small>1) \u30c7\u30fc\u30bf\u30ab\u30c3\u30c8\u30aa\u30d5\u6642\u70b9\u3067\u306fOS\u4e2d\u592e\u5024\u306b\u9054\u3057\u3066\u3044\u306a\u3044\u3002<br \/>\n2) 19\u4f8b\u306e\u767b\u9332\u60a3\u8005\u3055\u3093\u306e\u3046\u3061\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u691c\u8a0e\u53ef\u80fd\u306a17\u4f8b\u306b\u3064\u3044\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002<\/small><\/p>\n<p>\u7c73\u56fd\u30c6\u30ad\u30b5\u30b9\u5927\u5b66MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u304c\u3093\u30bb\u30f3\u30bf\u30fc Division of Surgery, Department of Head and Neck Surgery\u6559\u6388\u306eAnn M. Gillenwater\u6c0f\u306f\u3001\u672c\u30c7\u30fc\u30bf\u767a\u8868\u306b\u304a\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u300c\u9032\u884c\u982d\u9838\u90e8\u304c\u3093\u306f\u3001\u6cbb\u7642\u9078\u629e\u80a2\u304c\u9650\u3089\u308c\u3066\u304a\u308a\u3001\u6982\u306d\u4f4e\u3044\u751f\u5b58\u7387\u3068\u3001\u9ad8\u3044\u5c40\u6240\u518d\u767a\u7387\u304c\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6297PD-1\u6297\u4f53\u306f\u982d\u9838\u90e8\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u69d8\u3005\u306a\u304c\u3093\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306e\u7d50\u679c\u3092\u3082\u3068\u306b\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u3068\u6297PD-1\u6297\u4f53\u306e\u4f75\u7528\u7642\u6cd5\u304c\u518d\u767a\u982d\u9838\u90e8\u304c\u3093\u306b\u5bfe\u3057\u3066\u65b0\u305f\u306a\u9769\u65b0\u7684\u6cbb\u7642\u6cd5\u3068\u306a\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u3055\u3089\u306b\u691c\u8a0e\u3092\u9032\u3081\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002EGFR\u767a\u73fe\u306e\u3042\u308b\u304c\u3093\u7d30\u80de\u3068\u3001PD-1\u7d4c\u8def\u306e\u4e21\u65b9\u3092\u6a19\u7684\u306b\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6297\u816b\u760d\u514d\u75ab\u53cd\u5fdc\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001\u3069\u3061\u3089\u304b\u4e00\u65b9\u306e\u5358\u72ec\u7642\u6cd5\u306b\u6bd4\u3079\u3088\u308a\u6301\u7d9a\u7684\u3067\u3088\u308a\u52b9\u679c\u306e\u9ad8\u3044\u816b\u760d\u7e2e\u5c0f\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u300d<\/p>\n<p>\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30ebCo-CEO\u306e\u4e09\u6728\u8c37 \u6d69\u53f2\u306f\u3001\u300cASP-1929-181\u8a66\u9a13\u306e\u65e9\u671f\u8a55\u4fa1\u30c7\u30fc\u30bf\u306b\u304a\u3044\u3066\u3001\u6709\u671b\u306a\u7d50\u679c\u304c\u793a\u3055\u308c\u305f\u3053\u3068\u3092\u5927\u5909\u5b09\u3057\u304f\u601d\u3044\u307e\u3059\u3002\u6a19\u6e96\u6cbb\u7642\u3067\u3042\u308b\u6297PD-1\u6297\u4f53\u306bASP-1929\u3092\u7528\u3044\u305f\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u982d\u9838\u90e8\u304c\u3093\u6cbb\u7642\u3001\u3072\u3044\u3066\u306f\u304c\u3093\u6cbb\u7642\u5168\u4f53\u306b\u610f\u7fa9\u306e\u3042\u308b\u9032\u6b69\u304c\u3082\u305f\u3089\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u300d\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><span style=\"text-decoration: underline\"><strong>ASP-1929-181\u8a66\u9a13\u306e\u6982\u8981<\/strong><\/span><\/p>\n<p>\u672c\u8a66\u9a13\u306f\u3001EGFR\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u9032\u884c\u6027\u306e\u56fa\u5f62\u304c\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u6297EGFR\u6297\u4f53-\u5149\u611f\u53d7\u6027\u7269\u8cea\u8907\u5408\u4f53\u300cASP-1929\u300d\u3092\u7528\u3044\u305f\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\u3068\u6297PD-1\u6297\u4f53\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306b\u95a2\u3059\u308b\u975e\u76f2\u691c\u7b2c\u2160b \/\u2161\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u3059\u3002\u672c\u8a66\u9a13\u306f\u30011) \u518d\u767a\u53c8\u306f\u8ee2\u79fb\u6027\u5c40\u6240\u9032\u884c\u982d\u9838\u90e8\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u30012) \u5c40\u6240\u9032\u884c\u53c8\u306f\u8ee2\u79fb\u6027\u76ae\u819a\u6241\u5e73\u4e0a\u76ae\u304c\u3093\u30013) 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\/>\n<\/strong>\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\u306f\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u547c\u3076\u6280\u8853\u57fa\u76e4\u3092\u57fa\u306b\u3001\u85ac\u5264\u3068\u5149\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3001\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304a\u3088\u3073\u8ca9\u58f2\u3092\u884c\u3046\u30b0\u30ed\u30fc\u30d0\u30eb\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u57fa\u306b\u958b\u767a\u3057\u305f\u533b\u85ac\u54c1\u30fb\u533b\u7642\u6a5f\u5668\u306e\u975e\u81e8\u5e8a\u8a66\u9a13\uff08\u975e\u516c\u958b\u30c7\u30fc\u30bf\uff09\u3067\u306f\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306e\u9078\u629e\u7684\u306a\u58ca\u6b7b\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\u306f\u3001\u4e16\u754c\u4e2d\u306e\u4e00\u4eba\u3067\u3082\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306b\u3001\u4e00\u65e5\u3067\u3082\u65e9\u304f\u3001\u79c1\u305f\u3061\u306e\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u304a\u5c4a\u3051\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u300c\u30ac\u30f3\u514b\u670d\u3002\u300d\u3068\u3044\u3046\u30df\u30c3\u30b7\u30e7\u30f3\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u793e\u304c\u3042\u308b\u7c73\u56fd\u306b\u52a0\u3048\u3001\u65e5\u672c\u3001\u30aa\u30e9\u30f3\u30c0\u3001\u53f0\u6e7e\u3001\u30b9\u30a4\u30b9\u3001\u30a4\u30f3\u30c9\u306e\u4e16\u754c6\u30ab\u56fd\u306b\u62e0\u70b9\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u682a\u5f0f\u4f1a\u793e\u306f\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u793e\uff08\u7c73\u56fd\u6cd5\u4eba\uff09\u306e\u65e5\u672c\u6cd5\u4eba\u3067\u3059\u3002\u8a73\u3057\u304f\u306f\u3001<a href=\"https:\/\/rakuten-med.com\/jp\/\">https:\/\/rakuten-med.com\/jp\/<\/a>\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u3064\u3044\u3066<br 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2 \u6bb5\u968e\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u85ac\u5264\u306f\u3001\u5149\u611f\u53d7\u6027\u7269\u8cea (\u5149\u306b\u53cd\u5fdc\u3059\u308b\u7269\u8cea) \u3068\u3001\u30ad\u30e3\u30ea\u30a2 (\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3059\u308b\u6210\u5206) \u304b\u3089\u7d44\u6210\u3055\u308c\u308b\u8907\u5408\u4f53\u3067\u3059\u3002\u540c\u85ac\u5264\u3092\u6295\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3055\u305b\u305f\u5f8c\u3001\u305d\u306e\u7d30\u80de\u306b\u7279\u5b9a\u306e\u5149\u3092\u7167\u5c04\u3059\u308b\u3053\u3068\u3067\u5149\u611f\u53d7\u6027\u7269\u8cea\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u751f\u5316\u5b66\u30fb\u7269\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u7d30\u80de\u3092\u58ca\u6b7b\u3055\u305b\u3001\u3042\u308b\u3044\u306f\u3001\u6392\u9664\u3057\u307e\u3059\u3002<\/p>\n<p><strong>ASP-1929\u306b\u3064\u3044\u3066<br 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