{"id":8622,"date":"2025-03-13T14:00:29","date_gmt":"2025-03-13T05:00:29","guid":{"rendered":"https:\/\/rakuten-med.com\/jp\/?post_type=press_releases&#038;p=8622"},"modified":"2025-03-13T12:07:42","modified_gmt":"2025-03-13T03:07:42","slug":"%e6%8a%97pd-l1%e6%8a%97%e4%bd%93-%e8%89%b2%e7%b4%a0%e8%a4%87%e5%90%88%e4%bd%93%e3%81%a7%e3%81%82%e3%82%8b%e3%80%8crm-0256%e3%80%8d%e3%82%92%e7%94%a8%e3%81%84%e3%81%9f%e3%82%a2%e3%83%ab%e3%83%9f","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2025\/03\/13\/8622\/","title":{"rendered":"\u6297PD-L1\u6297\u4f53-\u8272\u7d20\u8907\u5408\u4f53\u3067\u3042\u308b\u300cRM-0256\u300d\u3092\u7528\u3044\u305f\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\uff08\u5149\u514d\u75ab\u7642\u6cd5\uff09\u306e\u958b\u767a\u304cAMED\u300c\u5275\u85ac\u652f\u63f4\u63a8\u9032\u4e8b\u696d\u30fb\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u6307\u5b9a\u524d\u5b9f\u7528\u5316\u652f\u63f4\u4e8b\u696d\u300d\u306b\u63a1\u629e"},"content":{"rendered":"<div id=\"pl-8622\"  class=\"panel-layout\" ><div id=\"pg-8622-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8622-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8622-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><b>- \u5e0c\u5c11\u75be\u60a3\u3067\u3042\u308b\u300c\u9032\u884c\u30fb\u518d\u767a\u306e\u4e0a\u76ae\u7cfb\u76ae\u819a\u60aa\u6027\u816b\u760d\u300d\u306b\u5bfe\u3057\u3066\u3001\u65b0\u3057\u3044\u4f5c\u7528\u6a5f\u5e8f\u3092\u6709\u3059\u308b<\/b><b>\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u9032\u3081\u3001\u65e9\u671f\u5b9f\u7528\u5316\u3092\u76ee\u6307\u3059-<\/b><\/p>\n<p><span style=\"font-weight: 400\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u682a\u5f0f\u4f1a\u793e\uff08\u672c\u793e\uff1a\u6771\u4eac\u90fd\u4e16\u7530\u8c37\u533a\u3001\u4ee3\u8868\u53d6\u7de0\u5f79\u4f1a\u9577\uff1a\u4e09\u6728\u8c37 \u6d69\u53f2\uff0f\u4ee5\u4e0b\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\uff09\u306f\u3001\u300c\u6297PD-L1\u6297\u4f53-\u8272\u7d20\u8907\u5408\u4f53\uff08RM-0256\uff09\u3092\u7528\u3044\u305f\u9032\u884c\u30fb\u518d\u767a\u306e\u4e0a\u76ae\u7cfb\u76ae\u819a\u60aa\u6027\u816b\u760d\u306e\u6cbb\u7642\u85ac\u306e\u958b\u767a\u300d\u306b\u3064\u3044\u3066\u3001\u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb\uff08\u4ee5\u4e0b\u3001AMED\uff09\u306b\u3088\u308b\u4ee4\u548c7\u5e74\u5ea6 \u300c\u5275\u85ac\u652f\u63f4\u63a8\u9032\u4e8b\u696d\u30fb\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u6307\u5b9a\u524d\u5b9f\u7528\u5316\u652f\u63f4\u4e8b\u696d\u300d\u306b\u63a1\u629e\u3055\u308c\u307e\u3057\u305f\u306e\u3067\u304a\u77e5\u3089\u305b\u3057\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u4e0a\u76ae\u7cfb\u76ae\u819a\u60aa\u6027\u816b\u760d\u306f\u3001\u76ae\u819a\u306b\u3067\u304d\u308b\u60aa\u6027\u816b\u760d\u306e\u3046\u3061\u3001\u4e0a\u76ae\u7d30\u80de\u304c\u304c\u3093\u5316\u3057\u305f\u3082\u306e\u3092\u6307\u3057\u307e\u3059\u3002\u6709\u68d8\u7d30\u80de\uff08\u3086\u3046\u304d\u3087\u304f\u3055\u3044\u307c\u3046\uff09\u304c\u3093\u3001\u57fa\u5e95\u7d30\u80de\uff08\u304d\u3066\u3044\u3055\u3044\u307c\u3046\uff09\u304c\u3093\u3001\u4e73\u623f\u5916\uff08\u306b\u3085\u3046\u307c\u3046\u304c\u3044\uff09\u30d1\u30b8\u30a7\u30c3\u30c8\u75c5\u3084\u3001\u6c57\u817a\uff08\u304b\u3093\u305b\u3093\uff09\u304c\u3093\u3001\u8102\u817a\uff08\u3057\u305b\u3093\uff09\u304c\u3093\u3001\u6bdb\u5305\uff08\u3082\u3046\u307b\u3046\uff09\u304c\u3093\u306a\u3069\u306e\u76ae\u819a\u4ed8\u5c5e\u5668\u304c\u3093\u304c\u542b\u307e\u308c\u307e\u3059<\/span><sup>1<\/sup><span style=\"font-weight: 400\">\u3002<\/span><span style=\"font-weight: 400\">\u65e5\u672c\u306b\u304a\u3051\u308b\u3001<\/span><span style=\"font-weight: 400\">\u4e0a\u76ae\u7cfb\u76ae\u819a\u60aa\u6027\u816b\u760d\u306e\u7f79\u60a3\u8005\u6570\u306f<\/span><span style=\"font-weight: 400\">\u5e74\u9593\u7d0422,000\u4eba\u3067\u3059<\/span><sup>2<\/sup><span style=\"font-weight: 400\">\u3002<\/span><span style=\"font-weight: 400\">\u9032\u884c\u30fb\u518d\u767a\u306e\u4e0a\u76ae\u7cfb\u76ae\u819a\u60aa\u6027\u816b\u760d\u306b<\/span><span style=\"font-weight: 400\">\u5bfe\u3057\u3066\u306f\u85ac\u7269\u7642\u6cd5\u304c\u4e2d\u5fc3\u3067\u3059\u304c\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306b\u8010\u6027\u306e\u3042\u308b\u60a3\u8005\u3055\u3093\u306b\u306f\u3001\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u304c\u306a\u3044\u3053\u3068\u304c\u8ab2\u984c\u3068\u3057\u3066\u3042\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u3053\u3068\u304b\u3089\u65b0\u3057\u3044\u4f5c\u7528\u6a5f\u5e8f\u3092\u6709\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">RM-0256\u306f\u3001\u7d30\u80de\u8868\u9762\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u30ea\u30ac\u30f3\u30c91\uff08Programmed cell Death Ligand 1\uff1aPD-L1\uff09\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u5b8c\u5168\u30d2\u30c8\u578b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\uff08\u6297PD-L1\u6297\u4f53\uff09\u3068\u5149\u611f\u53d7\u6027\u7269\u8cea\uff08\u5149\u306b\u53cd\u5fdc\u3059\u308b\u7269\u8cea\uff09\u3067\u3042\u308b\u8272\u7d20\u300cIRDye\u00ae 700DX\u300d\u3068\u306e\u8907\u5408\u4f53\u3067\u3001PD-L1\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306b\u7279\u7570\u7684\u306b\u96c6\u7a4d\u3057\u307e\u3059\u3002\u300c<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2024\/09\/20\/8584\/\"><span style=\"font-weight: 400\">PD-L1\u3092\u6a19\u7684\u3068\u3057\u305f\u5149\u514d\u75ab\u7642\u6cd5<\/span><\/a><span style=\"font-weight: 400\">\u300d\u306e\u975e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u672c\u6cbb\u7642\u304c\u300cPD-L1\u3092\u767a\u73fe\u3059\u308b\u816b\u760d\u7d30\u80de\u306e\u7834\u58ca\u300d\u3068\u300cPD-L1\u3092\u767a\u73fe\u3059\u308b\u514d\u75ab\u6291\u5236\u7d30\u80de\u306e\u6392\u9664\u300d\u306e2\u3064\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f<\/span><sup>3<\/sup><span style=\"font-weight: 400\">\u3002\u307e\u305f\u3001\u6297PD-L1\u6297\u4f53\u306b\u8010\u6027\u306e\u3042\u308b\u816b\u760d\u306b\u5bfe\u3059\u308b\u6297\u816b\u760d\u52b9\u679c\u3082\u793a\u3055\u308c\u307e\u3057\u305f<\/span><sup><span style=\"font-weight: 400\">3<\/span><\/sup><span style=\"font-weight: 400\">\u3002\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u72ec\u81ea\u306e\u6280\u8853\u57fa\u76e4\u3067\u3042\u308b\u300c\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u300d\u3092\u3082\u3068\u306b\u958b\u767a\u3055\u308c\u305fRM-0256\u3068\u30ec\u30fc\u30b6\u88c5\u7f6e\u3092\u7528\u3044\u3066\u3001\u5c40\u6240\u304a\u3088\u3073\u5168\u8eab\u306e\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u9032\u3081\u3001\u9032\u884c\u30fb\u518d\u767a\u306e\u4e0a\u76ae\u7cfb\u76ae\u819a\u60aa\u6027\u816b\u760d\u306b\u5bfe\u3059\u308b\u65e9\u671f\u5b9f\u7528\u5316\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb \u4ee3\u8868\u53d6\u7de0\u5f79\u793e\u9577 \u5c0f\u7389 \u88d5\u4e4b\u306f\u3001\u6b21\u306e\u3088\u3046\u306b\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u300c\u5f53\u793e\u306e\u5275\u85ac\u30d7\u30ed\u30b0\u30e9\u30e0\u300e<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/alluminox\/pipeline\/\"><span style=\"font-weight: 400\">\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u30d1\u30ec\u30c3\u30c8\u2122<\/span><\/a><span style=\"font-weight: 400\">\u300f\u306b\u304a\u3051\u308b3\u3064\u76ee\u306e\u8907\u5408\u4f53\u300eRM-0256\u300f\u3092\u7528\u3044\u305f\u65b0\u898f\u30e2\u30c0\u30ea\u30c6\u30a3\u306e\u958b\u767a\u304cAMED\u306b\u63a1\u629e\u3055\u308c\u3001\u5927\u5909\u5b09\u3057\u304f\u601d\u3044\u307e\u3059\u30022020\u5e74\u306b\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u65e5\u672c\u3067\u5b9f\u7528\u5316\u3055\u308c\u305fEGFR\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u300e<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2020\/09\/25\/7637\/\"><span style=\"font-weight: 400\">ASP-1929<\/span><\/a><span style=\"font-weight: 400\">\u300f\u3001AMED\u306e\u652f\u63f4\u306b\u3088\u308a\u30012023\u5e74\u306b\u81e8\u5e8a\u8a66\u9a13\u3092\u958b\u59cb\u3057\u305f\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u300e<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2023\/08\/03\/8425\/\"><span style=\"font-weight: 400\">RM-1995<\/span><\/a><span style=\"font-weight: 400\">\u300f\u306b\u7d9a\u304d\u3001\u300eRM-0256\u300f\u306e\u958b\u767a\u3082\u8fc5\u901f\u306b\u9032\u3081\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3092\u5f85\u3063\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u306b\u4e00\u65e5\u3067\u3082\u65e9\u304f\u300e\u5149\u300f\u3092\u304a\u5c4a\u3051\u3067\u304d\u308b\u3088\u3046\u52aa\u3081\u3066\u307e\u3044\u308a\u307e\u3059\u300d<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u300c\u5275\u85ac\u652f\u63f4\u63a8\u9032\u4e8b\u696d\u30fb\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u6307\u5b9a\u524d\u5b9f\u7528\u5316\u652f\u63f4\u4e8b\u696d\u300d\u306f\u3001\u5e0c\u5c11\u75be\u75c5\u7528\u533b\u85ac\u54c1\u6307\u5b9a\u524d\u306e\u6bb5\u968e\u306e\u958b\u767a\u3092\u63a8\u9032\u3059\u308b\u305f\u3081\u3001\u958b\u767a\u8cbb\u7528\u306e\u4e00\u90e8\u3092\u88dc\u52a9\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u30012025\u5e74\u5ea6\u304b\u3089\u6700\u5927\uff13\u4e8b\u696d\u5e74\u5ea6\u306e\u652f\u63f4\u3092\u53d7\u3051\u308b\u4e88\u5b9a\u3067\u3059\u30022025\u5e74\u5185\u306b\u6cbb\u9a13\u8a08\u753b\u5c4a\u63d0\u51fa\u3092\u76ee\u6307\u3057\u3001\u305d\u306e\u5f8c\u81e8\u5e8a\u8a66\u9a13\u3092\u958b\u59cb\u3057\u307e\u3059\u3002\u672c\u652f\u63f4\u4e8b\u696d\u306e\u8a73\u7d30\u306fAMED\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\uff08<\/span><a href=\"https:\/\/www.amed.go.jp\/program\/list\/11\/02\/001_03-01.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.amed.go.jp\/program\/list\/11\/02\/001_03-01.html<\/span><\/a><span style=\"font-weight: 400\">\uff09\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/span><\/p>\n<p><b>RM-0256\u306b\u3064\u3044\u3066<\/b><\/p>\n<p><span style=\"font-weight: 400\">\u300cRM-0256\u300d\u306f\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u304c\u958b\u767a\u3057\u305f\u6297PD-L1\u6297\u4f53\uff08\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\uff09\u3068\u5149\u611f\u53d7\u6027\u7269\u8cea\uff08\u5149\u306b\u53cd\u5fdc\u3059\u308b\u7269\u8cea\uff09\u3067\u3042\u308bIRDye\u00ae 700DX\uff08IR700\uff09\u306e\u8907\u5408\u4f53\u3067\u3001PD-L1\u3092\u767a\u73fe\u3059\u308b\u7d30\u80de\u306b\u7279\u7570\u7684\u306b\u96c6\u7a4d\u3057\u307e\u3059\u3002PD-L1\u306f\u3001\u6d3b\u6027\u5316T\u7d30\u80de\u306e\u8868\u9762\u306b\u591a\u304f\u767a\u73fe\u3059\u308bPD-1\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001T\u7d30\u80de\u304c\u6301\u3064\u816b\u760d\u7d30\u80de\u306a\u3069\u3078\u306e\u653b\u6483\u80fd\u529b\uff08\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\uff09\u3092\u6291\u5236\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067<\/span><sup>4<\/sup><span style=\"font-weight: 400\">\u3001\u591a\u304f\u306e\u56fa\u5f62\u304c\u3093\u3067\u767a\u73fe\u3057\u3066\u3044\u307e\u3059<\/span><sup>5<\/sup><span style=\"font-weight: 400\">\u3002\u307e\u305f\u3001\u816b\u760d\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u5185\u306e\u514d\u75ab\u6291\u5236\u7d30\u80de\u3067\u3042\u308b\u816b\u760d\u95a2\u9023\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u9aa8\u9ac4\u7531\u6765\u6291\u5236\u7d30\u80de\u306a\u3069\u306b\u3082\u767a\u73fe\u3057\u3066\u3044\u307e\u3059<\/span><sup>6<\/sup><span style=\"font-weight: 400\">\u3002\u6297PD-L1\u6297\u4f53-\u8272\u7d20\u8907\u5408\u4f53\u3092\u7528\u3044\u305f\u300cPD-L1\u3092\u6a19\u7684\u3068\u3057\u305f\u5149\u514d\u75ab\u7642\u6cd5\u300d\u306e\u975e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u6a19\u7684\u816b\u760d\u7d30\u80de\u306e\u7834\u58ca\u3068\u514d\u75ab\u6291\u5236\u7d30\u80de\u306e\u6392\u9664\u306b\u3088\u308a\u3001\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u306e\u6d3b\u6027\u5316\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u300cRM-0256\u300d\u306b\u3088\u308bPD-L1\u3068PD-1\u306e\u7d50\u5408\u306e\u963b\u5bb3\u3082\u793a\u3055\u308c\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u3068\u3057\u3066\u306e\u5168\u8eab\u7684\u306a\u4f5c\u7528\u306b\u3088\u308a\u3001\u672c\u6cbb\u7642\u5f8c\u306e\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u3055\u3089\u306b\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<div style=\"font-size: 0.9em\">\n<p><span style=\"font-weight: 400\">\u53c2\u8003\uff1a<\/span><\/p>\n<ol>\n<li><span style=\"font-weight: 400\"> \u65e5\u672c\u76ae\u819a\u60aa\u6027\u816b\u760d\u5b66\u4f1a\u7de8\uff0e\u76ae\u819a\u60aa\u6027\u816b\u760d\u53d6\u6271\u3044\u898f\u7d04 \u7b2c2\u7248\uff0e2010\u5e748\u6708\uff0e\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400\"> \u539a\u751f\u52b4\u50cd\u7701\u5065\u5eb7\u5c40\u304c\u3093\u30fb\u75be\u75c5\u5bfe\u7b56\u8ab2\u300c\u4ee4\u548c2\u5e74\u5168\u56fd\u304c\u3093\u767b\u9332 \u7f79\u60a3\u6570\u30fb\u7387 \u5831\u544a\u300d\u4ed8\u8868\uff11\uff0e\u7f79\u60a3\u6570\u3000\u76ae\u819a\u306e\u305d\u306e\u4ed6<\/span><a href=\"https:\/\/www.mhlw.go.jp\/content\/10900000\/001231386.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.mhlw.go.jp\/content\/10900000\/001231386.pdf<\/span><\/a><\/li>\n<li><span style=\"font-weight: 400\"> Thorne A. PD-L1 photoimmunotherapy kills immunosuppressive myeloid cells to activate local and systemic antitumor immunity. Abstract Number: 30050. The 83rd Annual Meeting of the Japanese Cancer Association. September 2024.<\/span><\/li>\n<li><span style=\"font-weight: 400\"> Lu C, Redd PS, Lee JR, Savage N, Liu K. The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells. OncoImmunology 2016;5:12, DOI: 10.1080\/2162402X.2016.1247135<\/span><\/li>\n<li><span style=\"font-weight: 400\"> Kythreotou A, Siddique A, Mauri FA, Bower M, Pinato D. PD-L1. Journal of Clinical Pathology\u00a0 2018;71:189-194. DOI: 10.1136\/jclinpath-2017-204853\u00a0<\/span><\/li>\n<li><span style=\"font-weight: 400\"> Shklovskaya E, Rizos H. Spatial and Temporal Changes in PD-L1 Expression in Cancer: The Role of Genetic Drivers, Tumor Microenvironment and Resistance to Therapy. International Journal of Molecular Sciences 2020, 21, 7139. DOI: 10.3390\/ijms21197139<\/span><\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-8622-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8622-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8622-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><b>\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u682a\u5f0f\u4f1a\u793e\u306b\u3064\u3044\u3066<\/b><\/p>\n<p><span style=\"font-weight: 400\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u547c\u3076\u6280\u8853\u57fa\u76e4\u3092\u57fa\u306b\u3001\u85ac\u5264\u3068\u5149\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3001\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304a\u3088\u3073\u8ca9\u58f2\u3092\u884c\u3046\u30b0\u30ed\u30fc\u30d0\u30eb\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u57fa\u306b\u958b\u767a\u3057\u305f\u533b\u85ac\u54c1\u30fb\u533b\u7642\u6a5f\u5668\u306e\u975e\u81e8\u5e8a\u8a66\u9a13\uff08\u975e\u516c\u958b\u30c7\u30fc\u30bf\uff09\u3067\u306f\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306e\u9078\u629e\u7684\u306a\u58ca\u6b7b\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u4e16\u754c\u4e2d\u306e\u4e00\u4eba\u3067\u3082\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306b\u3001\u4e00\u65e5\u3067\u3082\u65e9\u304f\u3001\u79c1\u305f\u3061\u306e\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u304a\u5c4a\u3051\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u300c\u30ac\u30f3\u514b\u670d\u3002\u300d\u3068\u3044\u3046\u30df\u30c3\u30b7\u30e7\u30f3\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u793e\u3092\u69cb\u3048\u308b\u7c73\u56fd\u306b\u52a0\u3048\u3001\u65e5\u672c\u3001\u53f0\u6e7e\u3001\u30b9\u30a4\u30b9\u3001\u30a4\u30f3\u30c9\u306e\u4e16\u754c5\u30ab\u56fd\/\u5730\u57df\u306b\u62e0\u70b9\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u682a\u5f0f\u4f1a\u793e\u306f\u3001Rakuten Medical, Inc.\uff08\u7c73\u56fd\u6cd5\u4eba\uff09\u306e\u65e5\u672c\u6cd5\u4eba\u3067\u3059\u3002\u8a73\u3057\u304f\u306f\u3001<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/\"><span style=\"font-weight: 400\">https:\/\/rakuten-med.com\/jp\/<\/span><\/a><span style=\"font-weight: 400\">\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/span><\/p>\n<p><b>\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u3064\u3044\u3066<\/b><span style=\"font-weight: 400\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u2122\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u6cbb\u7642\u6280\u8853\u57fa\u76e4\u306e\u540d\u79f0\u3067\u3042\u308a\u3001\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\u306e\u5c0f\u6797\u4e45\u9686\u5148\u751f\u3089\u304c\u958b\u767a\u3057\u305f\u304c\u3093\u5149\u514d\u75ab\u7642\u6cd5\u304c\u57fa\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u533b\u85ac\u54c1\u3001\u533b\u7642\u6a5f\u5668\u3001\u533b\u7642\u6280\u8853\u3001\u305d\u306e\u4ed6\u5468\u8fba\u6280\u8853\u3092\u7dcf\u5408\u7684\u306b\u5229\u7528\u3057\u305f\u6280\u8853\u57fa\u76e4\u3067\u3042\u308a\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u3053\u308c\u306b\u57fa\u3065\u304d\u88fd\u54c1\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u7528\u3044\u305f\u6cbb\u7642\u306f\u3001\u300c\u85ac\u5264\u306e\u6295\u4e0e\u300d\u3068\u300c\u5149\u306e\u7167\u5c04\u300d\u306e 2 \u6bb5\u968e\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u85ac\u5264\u306f\u3001\u5149\u611f\u53d7\u6027\u7269\u8cea (\u5149\u306b\u53cd\u5fdc\u3059\u308b\u7269\u8cea) \u3068\u3001\u30ad\u30e3\u30ea\u30a2 (\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3059\u308b\u6210\u5206) \u304b\u3089\u7d44\u6210\u3055\u308c\u308b\u8907\u5408\u4f53\u3067\u3059\u3002\u540c\u85ac\u5264\u3092\u6295\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3055\u305b\u305f\u5f8c\u3001\u305d\u306e\u7d30\u80de\u306b\u7279\u5b9a\u306e\u5149\u3092\u7167\u5c04\u3059\u308b\u3053\u3068\u3067\u5149\u611f\u53d7\u6027\u7269\u8cea\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u751f\u5316\u5b66\u30fb\u7269\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u7d30\u80de\u3092\u58ca\u6b7b\u3055\u305b\u3001\u3042\u308b\u3044\u306f\u3001\u6392\u9664\u3057\u307e\u3059\u3002<\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-8622-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8622-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8622-2-0-0\" class=\"so-panel widget widget_sow-button panel-first-child\" data-index=\"2\" ><div class=\"panel-widget-style panel-widget-style-for-8622-2-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-button so-widget-sow-button-flat-9f65a01042ab-8622\"\n\t\t\t\n\t\t><div class=\"ow-button-base ow-button-align-center\"\n>\n\t\t\t<a\n\t\t\t\t\thref=\"https:\/\/rakuten-med.com\/jp\/contact\/\"\n\t\t\t\t\tclass=\"rak-btn sowb-button ow-icon-placement-left ow-button-hover\" \t>\n\t\t<span>\n\t\t\t\n\t\t\t\u304a\u554f\u3044\u5408\u308f\u305b\u306f\u3053\u3061\u3089\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-8622-2-0-1\" class=\"widget_text so-panel widget widget_custom_html panel-last-child\" data-index=\"3\" ><div class=\"textwidget custom-html-widget\"><style>\n.so-widget-sow-image h3.widget-title {\n\tfont-size: inherit;\n\tfont-weight: normal;\n}\n\t\n\t.pink-heading-box table {\n\t\tborder-collapse: collapse;\n\t\tborder-left: 1px solid #000;\n\t\tborder-right: 1px solid #000;\n\t}\n\t.pink-heading-box table tr td, .pink-heading-box table tr th {\n    border: 1px solid #000;\n\t\tpadding: 8px;\n  }\n\t.pink-heading-box table tr th {\n    background-color: #f2f2f2;\n\t\tfont-weight:bold;\n  }\n\t.pink-heading-box table tr:first-child td, \n\t.pink-heading-box table tr:first-child th {\n\t\tborder-top: 1px solid #000;\n\t}\n\t.pink-heading-box table tr:last-child td, \n\t.pink-heading-box table tr:last-child th {\n\t\tborder-bottom: 1px solid #000;\n\t}\n\t.pink-heading-box table tr td:first-child,\n\t.pink-heading-box table tr th:first-child {\n\t\tborder-left: 0;\n\t}\n\n\t.pink-heading-box table tr td:last-child,\n\t.pink-heading-box table tr th:last-child {\n\t\tborder-right: 0;\n\t}\n<\/style><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>&#8211; 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