{"id":8779,"date":"2026-04-22T08:00:29","date_gmt":"2026-04-21T23:00:29","guid":{"rendered":"https:\/\/rakuten-med.com\/jp\/?post_type=press_releases&#038;p=8779"},"modified":"2026-04-21T17:56:25","modified_gmt":"2026-04-21T08:56:25","slug":"%e6%a5%bd%e5%a4%a9%e3%83%a1%e3%83%87%e3%82%a3%e3%82%ab%e3%83%ab%e3%80%81aacr-2026%e3%81%a7%e6%96%b0%e3%81%9f%e3%81%aa%e9%9d%9e%e8%87%a8%e5%ba%8a%e3%83%87%e3%83%bc%e3%82%bf%e3%82%92%e3%83%9d%e3%82%b9","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2026\/04\/22\/8779\/","title":{"rendered":"\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u3001AACR 2026\u3067\u65b0\u305f\u306a\u975e\u81e8\u5e8a\u30c7\u30fc\u30bf\u3092\u30dd\u30b9\u30bf\u30fc\u767a\u8868\uff1a COX-2\u963b\u5bb3\u304cPGE2\u306e\u7523\u751f\u6291\u5236\u3092\u901a\u3058\u3066\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\uff08\u5149\u514d\u75ab\u7642\u6cd5\uff09\u306b\u4f34\u3046\u6d6e\u816b\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027"},"content":{"rendered":"<div id=\"pl-8779\"  class=\"panel-layout\" ><div id=\"pg-8779-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8779-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8779-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><em>- \u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306eCOX-2\u3092\u4ecb\u3057\u305fPGE<sub>2<\/sub>\u7523\u751f\u306b\u3088\u308a\u3001\u6d6e\u816b\u304c\u5f62\u6210\u3055\u308c\u308b\u53ef\u80fd\u6027\u3092\u521d\u3081\u3066\u78ba\u8a8d<\/em><\/strong><br \/>\n<strong><em>- COX\u963b\u5bb3\u85ac\u306e\u4e88\u9632\u7684\u6295\u4e0e\u304c\u3001\u6d6e\u816b\u8efd\u6e1b\u304a\u3088\u3073\u6cbb\u7642\u306e\u3055\u3089\u306a\u308b\u5b89\u5168\u6027\u5411\u4e0a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506<\/em><\/strong><\/p>\n<p><span style=\"font-weight: 400\">Rakuten Medical, Inc.\uff08\u672c\u793e\uff1a\u7c73\u56fd \u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5dde \u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\uff0f\u4ee5\u4e0b\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\uff09\u306f\u30012026\u5e744\u670821\u65e5\uff08\u7c73\u56fd\u6642\u9593\uff09\u3001\u7c73\u56fd\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3067\u958b\u50ac\u3055\u308c\u305f2026\u5e74\u7c73\u56fd\u764c\u5b66\u4f1a\uff08American Association for Cancer Research\uff1aAACR\uff09\u5e74\u6b21\u7dcf\u4f1a\uff08\u4ee5\u4e0b\u3001AACR 2026\uff09\u306b\u304a\u3044\u3066\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\uff08\u5149\u514d\u75ab\u7642\u6cd5\uff09\u306b\u4f34\u3046\u6d6e\u816b\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u304a\u3088\u3073COX-2\u963b\u5bb3\u306b\u3088\u308b\u6d6e\u816b\u8efd\u6e1b\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u975e\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u3092\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">COX-2\u306f\u3001\u708e\u75c7\u3084\u7d44\u7e54\u969c\u5bb3\u306a\u3069\u306e\u523a\u6fc0\u306b\u3088\u308a\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u308b\u9175\u7d20\u3067\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u975e\u81e8\u5e8a\u7814\u7a76\u306b\u304a\u3044\u3066\u3001<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2024\/04\/12\/8541\/\"><span style=\"font-weight: 400\">COX-2\u9078\u629e\u7684\u963b\u5bb3\u85ac\u306e\u4e88\u9632\u7684\u6295\u4e0e\u306b\u3088\u308a\u3001\u5149\u514d\u75ab\u7642\u6cd5\u306b\u4f34\u3046\u6d6e\u816b\u306e\u4f53\u7a4d\u304c30-50%\u6e1b\u5c11<\/span><\/a><span style=\"font-weight: 400\">\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u8e0f\u307e\u3048\u3066\u5b9f\u65bd\u3055\u308c\u305f\u4eca\u56de\u306e\u975e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306eCOX-2\u767a\u73fe\u8a98\u5c0e\u3068\u30d7\u30ed\u30b9\u30bf\u30b0\u30e9\u30f3\u30b8\u30f3E<\/span><sub>2<\/sub><span style=\"font-weight: 400\">\uff08PGE<\/span><sub>2<\/sub><span style=\"font-weight: 400\">\uff09\u306e\u7523\u751f\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002COX-2\u9078\u629e\u7684\u963b\u5bb3\u85ac\u307e\u305f\u306f\u975e\u9078\u629e\u7684COX\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001COX-2\u306e\u767a\u73fe\u305d\u306e\u3082\u306e\u306f\u6291\u5236\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001PGE<\/span><sub>2<\/sub><span style=\"font-weight: 400\">\u306e\u7523\u751f\u306f\u6291\u5236\u3055\u308c\u307e\u3057\u305f\u3002PGE<\/span><sub>2<\/sub><span style=\"font-weight: 400\">\u306f\u3001\u708e\u75c7\u6761\u4ef6\u4e0b\u3067\u306f\u4e3b\u306bCOX\u20112\u6d3b\u6027\u3092\u4ecb\u3057\u3066\u7523\u751f\u3055\u308c\u3001\u8840\u7ba1\u900f\u904e\u6027\u3092\u9ad8\u3081\u308b\u3053\u3068\u3067\u6d6e\u816b\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u306a\u304a\u3001COX\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u306b\u3088\u308b\u6297\u816b\u760d\u52b9\u679c\u306e\u4f4e\u4e0b\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u5149\u514d\u75ab\u7642\u6cd5\u306b\u4f34\u3046\u6d6e\u816b\u304c\u3001COX-2\u306e\u767a\u73fe\u8a98\u5c0e\u3068\u3001COX-2\u6d3b\u6027\u3092\u4ecb\u3057\u305fPGE<\/span><sub>2<\/sub><span style=\"font-weight: 400\">\u7523\u751f\u306b\u3088\u308a\u5f62\u6210\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3059\u3068\u3068\u3082\u306b\u3001COX\u963b\u5bb3\u85ac\u306b\u3088\u308b\u4e88\u9632\u7684\u4ecb\u5165\u304c\u6d6e\u816b\u8efd\u6e1b\u306b\u6709\u7528\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u304c\u72ec\u81ea\u306e\u6280\u8853\u57fa\u76e4\u300c\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u00ae\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u300d\u3092\u57fa\u306b\u958b\u767a\u3059\u308b\u5149\u514d\u75ab\u7642\u6cd5\u306f\u3001\u6a19\u7684\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3059\u308b\u85ac\u5264\u3092\u6295\u4e0e\u3057\u305f\u5f8c\u3001\u30ec\u30fc\u30b6\u5149\u7167\u5c04\u306b\u3088\u308a\u6a19\u7684\u7d30\u80de\u306e\u7d30\u80de\u819c\u3092\u9078\u629e\u7684\u304b\u3064\u6025\u901f\u306b\u969c\u5bb3\u3057\u3001\u58ca\u6b7b\u3055\u305b\u308b\u6cbb\u7642\u6cd5\u3067\u3059\u3002\u65e9\u671f\u81e8\u5e8a\u8a66\u9a13<\/span><sup>1<\/sup><span style=\"font-weight: 400\">\u304a\u3088\u3073\u5b9f\u81e8\u5e8a<\/span><sup>2<\/sup><span style=\"font-weight: 400\">\u306b\u304a\u3044\u3066\u3001\u982d\u9838\u90e8\u304c\u3093\u306b\u5bfe\u3059\u308b\u7ba1\u7406\u53ef\u80fd\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u6ce8\u610f\u3059\u3079\u304d\u6709\u5bb3\u4e8b\u8c61\u306e\u4e00\u3064\u306b\u6d6e\u816b\u304c\u3042\u308a\u3001\u820c\u816b\u8139\u3084\u5589\u982d\u6d6e\u816b\u306b\u3088\u308a\u6c17\u9053\u9589\u585e\u306e\u304a\u305d\u308c\u304c\u3042\u308b\u5834\u5408\u306b\u306f\u4e88\u9632\u7684\u6c17\u7ba1\u5207\u958b\u7b49\u306e\u5bfe\u5fdc\u304c\u5fc5\u8981\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u3088\u308a\u8ca0\u62c5\u306e\u5c11\u306a\u3044\u65b0\u305f\u306a\u6d6e\u816b\u3078\u306e\u5bfe\u51e6\u6cd5\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p><a href=\"https:\/\/rakuten-med.com\/jp\/news\/press-releases\/2024\/09\/27\/8590\/\"><span style=\"font-weight: 400\">\u5149\u514d\u75ab\u7642\u6cd5\u306b\u4f34\u3046\u6d6e\u816b\u306e\u5bfe\u51e6\u6cd5\u306b\u3064\u3044\u3066\u306f\u3001\u7279\u5b9a\u81e8\u5e8a\u7814\u7a76\u3068\u3057\u3066\u5b9f\u81e8\u5e8a\u4e0b\u3067\u3082\u691c\u8a0e<\/span><\/a><span style=\"font-weight: 400\">\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u4eca\u56de\u306e\u7814\u7a76\u7d50\u679c\u3084\u672c\u7279\u5b9a\u81e8\u5e8a\u7814\u7a76\u306e\u6210\u679c\u3092\u3082\u3068\u306b\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u6cbb\u7642\uff08\u5149\u514d\u75ab\u7642\u6cd5\uff09\u306e\u3055\u3089\u306a\u308b\u5b89\u5168\u6027\u5411\u4e0a\u3068\u60a3\u8005\u3055\u3093\u306e\u8ca0\u62c5\u8efd\u6e1b\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/span><\/p>\n<p><b>AACR 2026\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u3000\u6982\u8981<\/b><\/p>\n<p><b>\u30bf\u30a4\u30c8\u30eb\uff1aCOX-2\/PGE<sub>2<\/sub> driven, photoimmunotherapy-induced edema is reduced by prophylactic NSAIDs in mouse tumor models<\/b><\/p>\n<p><span style=\"font-weight: 400\">\u30dd\u30b9\u30bf\u30fc\u30ea\u30f3\u30af\uff1a<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/wp-content\/uploads\/sites\/8\/2026\/04\/Amantea-4297-AACR-2026-poster.pdf\" target=\"_blank\" rel=\"noopener\">View\/Download Poster [PDF]<\/a><\/p>\n<p><span style=\"font-weight: 400\">\u6284\u9332\u756a\u53f7\uff1a4297<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u6284\u9332\u30ea\u30f3\u30af\uff1a<\/span><a href=\"https:\/\/www.abstractsonline.com\/pp8\/#!\/21436\/presentation\/5131\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.abstractsonline.com\/pp8\/#!\/21436\/presentation\/5131<\/span><\/a><\/p>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">in vitro\u8a66\u9a13\u3067\u306f\u3001Ephrin A2\uff08EphA2\uff09\u3092\u767a\u73fe\u3059\u308bCT26\u816b\u760d\u30e2\u30c7\u30eb\u304a\u3088\u3073LL2\u816b\u760d\u30e2\u30c7\u30eb\u306b\u3001\u6297EphA2\u6297\u4f53-IR700\u8907\u5408\u4f53\u3092\u6295\u4e0e\u3057\u3001\u5149\u7167\u5c04\u306e\u6709\u7121\u306b\u5206\u3051\u3066COX-2\u306e\u767a\u73fe\u72b6\u6cc1\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u304a\u3088\u3073\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u306b\u3088\u308a\u8a55\u4fa1\u3057\u305f\u3068\u3053\u308d\u3001\u3044\u305a\u308c\u306e\u30e2\u30c7\u30eb\u3067\u3082\u5149\u7167\u5c04\u3057\u305f\u5834\u5408\u306bCOX-2\u767a\u73fe\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">COX-2\u9078\u629e\u7684\u963b\u5bb3\u85ac\u30ed\u30d9\u30ca\u30b3\u30ad\u30b7\u30d6\u3001\u307e\u305f\u306f\u975e\u9078\u629e\u7684COX\u963b\u5bb3\u85ac\u30d5\u30eb\u30eb\u30d3\u30d7\u30ed\u30d5\u30a7\u30f3\u3068\u306e\u5171\u57f9\u990a\u4e0b\u3067\u3082\u3001\u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306eCOX-2\u767a\u73fe\u5897\u52a0\u304c\u78ba\u8a8d\u3055\u308c\u3001\u4e21\u5264\u306b\u3088\u308bCOX-2\u767a\u73fe\u6291\u5236\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">COX-2\u306e\u4e0b\u6d41\u56e0\u5b50\u3067\u3042\u308a\u8840\u7ba1\u900f\u904e\u6027\u4ea2\u9032\u306b\u95a2\u4e0e\u3059\u308bPGE<\/span><sub><span style=\"font-weight: 400\">2<\/span><\/sub><span style=\"font-weight: 400\">\u306b\u7740\u76ee\u3057\u3001ELISA\u6cd5\u3092\u7528\u3044\u3066\u7d30\u80de\u57f9\u990a\u6db2\u4e2d\u306ePGE<\/span><sub><span style=\"font-weight: 400\">2<\/span><\/sub><span style=\"font-weight: 400\">\u5206\u6ccc\u91cf\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001\u5149\u514d\u75ab\u7642\u6cd5\u76f4\u5f8c\u306bPGE<\/span><sub><span style=\"font-weight: 400\">2<\/span><\/sub><span style=\"font-weight: 400\">\u6fc3\u5ea6\u306e\u4e0a\u6607\u304c\u78ba\u8a8d\u3055\u308c\u305f<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">in vivo\u8a66\u9a13\u3067\u306f\u3001\u4e21\u5264\u306e\u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306e\u6d6e\u816b\u8efd\u6e1b\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001CT26-EphA2 \u307e\u305f\u306f LL2-EphA2 \u816b\u760d\u3092\u6709\u3059\u308b\u30de\u30a6\u30b9\u306b\u3001\u6297 EphA2\u6297\u4f53-IR700\u8907\u5408\u4f53\u3092\u6295\u4e0e\u3057\u3001\u5149\u7167\u5c04\u306e\u6709\u7121\u306b\u5206\u3051\u3066\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001\u3053\u308c\u307e\u3067\u306e\u30c7\u30fc\u30bf\u3068\u540c\u69d8\u3001\u6d6e\u816b\u306f\u5149\u514d\u75ab\u7642\u6cd5\u306e 6 \u6642\u9593\u5f8c\u306b\u30d4\u30fc\u30af\u306b\u9054\u3057\u305f<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u3053\u308c\u3089\u306e\u30de\u30a6\u30b9\u306b\u3044\u305a\u308c\u304b\u306e COX \u963b\u5bb3\u85ac\u3092\u524d\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u3001\u6d6e\u816b\u306f\u6709\u610f\u306b\u8efd\u6e1b\u3055\u308c\u305f (p<\/span><span style=\"font-weight: 400\">\u2264<\/span><span style=\"font-weight: 400\">0.0001)<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">COX-2\u306e\u95a2\u4e0e\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u3001\u816b\u760d\u6eb6\u89e3\u6db2\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306bCOX-2\u767a\u73fe\u306f\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u4e00\u65b9\u3001COX-1\u767a\u73fe\u306b\u306f\u5909\u5316\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3044\u305a\u308c\u306eCOX\u963b\u5bb3\u85ac\u306e\u6295\u4e0e\u4e0b\u3067\u3082COX-2\u767a\u73fe\u306e\u4f4e\u4e0b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306e\u5faa\u74b0\u8840\u4e2d\u306ePGE<\/span><sub><span style=\"font-weight: 400\">2<\/span><\/sub><span style=\"font-weight: 400\">\u4ee3\u8b1d\u7269\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001in vitro\u8a66\u9a13\u3068\u540c\u69d8\u3001PGE<\/span><sub><span style=\"font-weight: 400\">2<\/span><\/sub><span style=\"font-weight: 400\">\u306e\u5897\u52a0\u304c\u78ba\u8a8d\u3055\u308c\u305f\u304c\u3001COX\u963b\u5bb3\u85ac\u6295\u4e0e\u4e0b\u3067\u306f\u3053\u306e\u5897\u52a0\u306f\u78ba\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u30d2\u30c8\u4e0b\u54bd\u982d\u304c\u3093\u7d30\u80de\u3092\u7528\u3044\u305f\u982d\u9838\u90e8\u304c\u3093\u7570\u7a2e\u79fb\u690d\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3082\u3001\u6d6e\u816b\u306f\u5149\u514d\u75ab\u7642\u6cd5\u306e6\u6642\u9593\u5f8c\u306b\u30d4\u30fc\u30af\u306b\u9054\u3057\u3001\u3044\u305a\u308c\u306eCOX\u963b\u5bb3\u85ac\u306b\u3088\u3063\u3066\u3082\u6d6e\u816b\u306f\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u305f\uff08p<\/span><span style=\"font-weight: 400\">\u2264<\/span><span style=\"font-weight: 400\">0.0001\uff09<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">COX\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6297\u816b\u760d\u52b9\u679c\u306e\u4f4e\u4e0b\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ol style=\"font-size: 0.8em\">\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Cognetti DM, Johnson JM, Curry JM, et al. Phase 1\/2a, open\u2011label, multicenter study of RM\u20111929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma. Head Neck. 2021;43(12):3875\u20133887. doi:10.1002\/hed.26885<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Shinozaki T, et al. Real\u2011world clinical experience with ASP\u20111929 photoimmunotherapy in head and neck cancer. 34th Annual Meeting of the Japanese Society for Head and Neck Surgery; January 2025.<\/span><\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-8779-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8779-1-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8779-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><b>\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306b\u3064\u3044\u3066<br \/>\n<\/b><span style=\"font-weight: 400\">\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u00ae\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3068\u547c\u3076\u6280\u8853\u57fa\u76e4\u3092\u57fa\u306b\u3001\u85ac\u5264\u3068\u5149\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u3001\u304c\u3093\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304a\u3088\u3073\u8ca9\u58f2\u3092\u884c\u3046\u30b0\u30ed\u30fc\u30d0\u30eb\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u57fa\u306b\u958b\u767a\u3057\u305f\u533b\u85ac\u54c1\u30fb\u533b\u7642\u6a5f\u5668\u306e\u975e\u81e8\u5e8a\u8a66\u9a13\uff08\u975e\u516c\u958b\u30c7\u30fc\u30bf\uff09\u3067\u306f\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306e\u9078\u629e\u7684\u306a\u58ca\u6b7b\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u4e16\u754c\u4e2d\u306e\u4e00\u4eba\u3067\u3082\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306b\u3001\u4e00\u65e5\u3067\u3082\u65e9\u304f\u3001\u79c1\u305f\u3061\u306e\u9769\u65b0\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u304a\u5c4a\u3051\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u300c\u30ac\u30f3\u514b\u670d\u3002\u300d\u3068\u3044\u3046\u30df\u30c3\u30b7\u30e7\u30f3\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u672c\u793e\u3092\u69cb\u3048\u308b\u7c73\u56fd\u306b\u52a0\u3048\u3001\u65e5\u672c\u3001\u53f0\u6e7e\u3001\u30b9\u30a4\u30b9\u3001\u30a4\u30f3\u30c9\u306e\u4e16\u754c5\u30ab\u56fd\/\u5730\u57df\u306b\u62e0\u70b9\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u682a\u5f0f\u4f1a\u793e\u306f\u3001Rakuten Medical, Inc.\uff08\u7c73\u56fd\u6cd5\u4eba\uff09\u306e\u65e5\u672c\u6cd5\u4eba\u3067\u3059\u3002\u8a73\u3057\u304f\u306f\u3001<\/span><a href=\"https:\/\/rakuten-med.com\/jp\/\"><span style=\"font-weight: 400\">https:\/\/rakuten-med.com\/jp\/<\/span><\/a><span style=\"font-weight: 400\"> \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/span><\/p>\n<p><b>\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u00ae\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306b\u3064\u3044\u3066<br \/>\n<\/b><span style=\"font-weight: 400\">\u30a2\u30eb\u30df\u30ce\u30c3\u30af\u30b9\u00ae\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u6cbb\u7642\u6280\u8853\u57fa\u76e4\u306e\u540d\u79f0\u3067\u3042\u308a\u3001\u7c73\u56fd\u56fd\u7acb\u304c\u3093\u7814\u7a76\u6240\u306e\u5c0f\u6797\u4e45\u9686\u5148\u751f\u3089\u304c\u958b\u767a\u3057\u305f\u304c\u3093\u5149\u514d\u75ab\u7642\u6cd5\u304c\u57fa\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u533b\u85ac\u54c1\u3001\u533b\u7642\u6a5f\u5668\u3001\u533b\u7642\u6280\u8853\u3001\u305d\u306e\u4ed6\u5468\u8fba\u6280\u8853\u3092\u7dcf\u5408\u7684\u306b\u5229\u7528\u3057\u305f\u6280\u8853\u57fa\u76e4\u3067\u3042\u308a\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\u306f\u3001\u3053\u308c\u306b\u57fa\u3065\u304d\u88fd\u54c1\u3084\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u540c\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3092\u7528\u3044\u305f\u6cbb\u7642\u306f\u3001\u300c\u85ac\u5264\u306e\u6295\u4e0e\u300d\u3068\u300c\u5149\u306e\u7167\u5c04\u300d\u306e 2 \u6bb5\u968e\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002\u85ac\u5264\u306f\u3001\u5149\u611f\u53d7\u6027\u7269\u8cea (\u5149\u306b\u53cd\u5fdc\u3059\u308b\u7269\u8cea) \u3068\u3001\u30ad\u30e3\u30ea\u30a2 (\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3059\u308b\u6210\u5206) \u304b\u3089\u7d44\u6210\u3055\u308c\u308b\u8907\u5408\u4f53\u3067\u3059\u3002\u540c\u85ac\u5264\u3092\u6295\u4e0e\u3057\u3001\u7279\u5b9a\u306e\u7d30\u80de\u306b\u9078\u629e\u7684\u306b\u96c6\u7a4d\u3055\u305b\u305f\u5f8c\u3001\u305d\u306e\u7d30\u80de\u306b\u7279\u5b9a\u306e\u5149\u3092\u7167\u5c04\u3059\u308b\u3053\u3068\u3067\u5149\u611f\u53d7\u6027\u7269\u8cea\u3092\u6d3b\u6027\u5316\u3055\u305b\u3001\u751f\u5316\u5b66\u30fb\u7269\u7406\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u7d30\u80de\u3092\u58ca\u6b7b\u3055\u305b\u3001\u3042\u308b\u3044\u306f\u3001\u6392\u9664\u3057\u307e\u3059\u3002<\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-8779-2\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-8779-2-0\"  class=\"panel-grid-cell\" ><div id=\"panel-8779-2-0-0\" class=\"so-panel widget widget_sow-button panel-first-child\" data-index=\"2\" ><div class=\"panel-widget-style panel-widget-style-for-8779-2-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-button so-widget-sow-button-flat-9f65a01042ab-8779\"\n\t\t\t\n\t\t><div class=\"ow-button-base ow-button-align-center\"\n>\n\t\t\t<a\n\t\t\t\t\thref=\"https:\/\/rakuten-med.com\/jp\/contact\/\"\n\t\t\t\t\tclass=\"rak-btn sowb-button ow-icon-placement-left ow-button-hover\" \t>\n\t\t<span>\n\t\t\t\n\t\t\t\u304a\u554f\u3044\u5408\u308f\u305b\u306f\u3053\u3061\u3089\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-8779-2-0-1\" class=\"widget_text so-panel widget widget_custom_html panel-last-child\" data-index=\"3\" ><div class=\"textwidget custom-html-widget\"><style>\n.so-widget-sow-image .widget-title {\n\ttext-align: center;\n\tmargin: 1em 0 !important;\n}\n\n.so-widget-sow-image h3.widget-title {\n\tfont-size: inherit;\n\tfont-weight: normal;\n}\n\t\n\t.pink-heading-box table {\n\t\tborder-collapse: collapse;\n\t\tborder-left: 1px solid #000;\n\t\tborder-right: 1px solid #000;\n\t}\n\t.pink-heading-box table tr td, .pink-heading-box table tr th {\n    border: 1px solid #000;\n\t\tpadding: 8px;\n  }\n\t.pink-heading-box table tr th {\n    background-color: #f2f2f2;\n\t\tfont-weight:bold;\n  }\n\t.pink-heading-box table tr:first-child td, \n\t.pink-heading-box table tr:first-child th {\n\t\tborder-top: 1px solid #000;\n\t}\n\t.pink-heading-box table tr:last-child td, \n\t.pink-heading-box table tr:last-child th {\n\t\tborder-bottom: 1px solid #000;\n\t}\n\t.pink-heading-box table tr td:first-child,\n\t.pink-heading-box table tr th:first-child {\n\t\tborder-left: 0;\n\t}\n\n\t.pink-heading-box table tr td:last-child,\n\t.pink-heading-box table tr th:last-child {\n\t\tborder-right: 0;\n\t}\n<\/style><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>&#8211; \u5149\u514d\u75ab\u7642\u6cd5\u5f8c\u306eCOX-2\u3092\u4ecb\u3057\u305fPGE2\u7523\u751f\u306b\u3088\u308a\u3001\u6d6e\u816b\u304c\u5f62\u6210\u3055\u308c\u308b\u53ef\u80fd\u6027\u3092\u521d\u3081\u3066\u78ba\u8a8d &#8211; COX\u963b\u5bb3\u85ac\u306e\u4e88\u9632\u7684\u6295\u4e0e\u304c\u3001\u6d6e\u816b\u8efd\u6e1b\u304a\u3088\u3073\u6cbb\u7642\u306e\u3055\u3089\u306a\u308b\u5b89\u5168\u6027\u5411\u4e0a\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506 Rakuten Medical, Inc.\uff08\u672c\u793e\uff1a\u7c73\u56fd \u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5dde \u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\uff0f\u4ee5\u4e0b\u3001\u697d\u5929\u30e1\u30c7\u30a3\u30ab\u30eb\uff09\u306f\u30012026\u5e744\u670821\u65e5\uff08\u7c73\u56fd\u6642\u9593\uff09\u3001\u7c73\u56fd\u30b5\u30f3\u30c7\u30a3\u30a8\u30b4\u3067\u958b\u50ac\u3055\u308c\u305f2026\u5e74\u7c73\u56fd\u764c\u5b66\u4f1a\uff08American Association for Cancer Research\uff1aAACR\uff09\u5e74\u6b21\u7dcf\u4f1a\uff08\u4ee5\u4e0b\u3001AACR 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