{"id":7542,"date":"2021-12-16T09:00:24","date_gmt":"2021-12-16T01:00:24","guid":{"rendered":"https:\/\/rakuten-med.com\/tw\/?post_type=press_releases&#038;p=7542"},"modified":"2022-04-20T12:26:39","modified_gmt":"2022-04-20T04:26:39","slug":"%e6%a8%82%e5%a4%a9%e9%86%ab%e8%97%a5%e5%ae%a3%e5%b8%83%e7%be%8e%e5%9c%8b%e9%a3%9f%e5%93%81%e5%92%8c%e8%97%a5%e7%89%a9%e7%ae%a1%e7%90%86%e5%b1%80%e5%b7%b2%e6%8e%a5%e5%8f%97rm-1995%e6%96%b0%e8%97%a5","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/tw\/news\/press-releases\/2021\/12\/16\/7542\/","title":{"rendered":"\u6a02\u5929\u91ab\u85e5\u5ba3\u5e03\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\u5df2\u63a5\u53d7RM-1995\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57 (IND)\u7533\u8acb"},"content":{"rendered":"<div id=\"pl-7542\"  class=\"panel-layout\" ><div id=\"pg-7542-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-7542-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-7542-0-0-0\" class=\"so-panel widget 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\u93c8(CD25)\u7684\u55ae\u682a\u6297\u9ad4\u8907\u5408\u7269\u3002\u5668\u6750\u90e8\u5206\u662f\u642d\u914dPIT690\u96f7\u5c04\u7cfb\u7d71\uff0c\u767c\u51fa690nm\u7684\u975e\u71b1\u7d05\u5149\u4f86\u6d3b\u5316IR700\u3002CD25\u55ae\u682a\u6297\u9ad4\u7684\u90e8\u5206\u5247\u662f\u91dd\u5c0d\u816b\u7624\u5167\u90e8\u7684\u8abf\u7bc0T\u7d30\u80de (Tregs)\uff0c\u56e0\u70ba\u8abf\u7bc0T\u7d30\u80de\u6703\u6291\u5236\u6297\u764c\u514d\u75ab\u53cd\u61c9\uff0c\u5e6b\u52a9\u816b\u7624\u751f\u9577[1]\u3002\u6a02\u5929\u91ab\u85e5\u7814\u7a76\u5c07RM-1995\u505a\u70ba\u4e00\u7a2e\u53ef\u80fd\u7684\u65b0\u6cbb\u7642\u65b9\u6cd5\uff0c\u5c08\u4e00\u6027\u7684\u76f4\u63a5\u6e1b\u5c11\u816b\u7624\u5167\u7684\u8abf\u7bc0T\u7d30\u80de\uff0c\u53ef\u671b\u8a98\u5c0e\u5168\u8eab\u514d\u75ab\u53cd\u61c9\u4f86\u5c0d\u6297\u764c\u75c7\u3002<\/p>\n<p>\u00a0<\/p>\n<p>\u300c\u6211\u5011\u5f88\u9ad8\u8208\u80fd\u5c07 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\u662f\u57fa\u65bcAlluminox\u2122<sup>TM<\/sup>\u5e73\u53f0\u958b\u767c\u7684\u7b2c\u4e00\u7a2e\u85e5\u7269\u3002\u8a72\u85e5\u7269\u5df2\u7372\u65e5\u672c\u539a\u751f\u52de\u52d5\u7701\u6838\u51c6\uff0c\u800c\u5728\u65e5\u672c\u4ee5\u5916\u7684\u5e02\u5834\u76ee\u524d\u6b63\u5728\u5168\u7403\u9032\u884c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u6a02\u5929\u91ab\u85e5\u4ee5\u6230\u52dd\u764c\u75c7\u70ba\u5df1\u4efb\uff0c\u65e8\u5728\u5275\u7acb\u4e00\u500b\u70ba\u764c\u75c7\u60a3\u8005\u63d0\u9ad8\u751f\u6d3b\u54c1\u8cea\u7684\u793e\u6703\u3002\u6a02\u5929\u91ab\u85e5\u76ee\u524d\u5728\u5168\u7403\u4e94\u500b\u570b\u5bb6\u6709\u516d\u500b\u8fa6\u516c\u64da\u9ede\uff0c\u5305\u542b\u7f8e\u570b\u7e3d\u90e8\u3001\u65e5\u672c\u3001\u8377\u862d\u3001\u53f0\u7063\u8207\u745e\u58eb\u3002\u66f4\u591a\u8a0a\u606f\u8acb\u53c3\u8a2a<a href=\"http:\/\/www.rakuten-med.com\/tw\/\">www.rakuten-med.com\/tw\/<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u95dc\u65bcRM-1995<\/p>\n<p>RM-1995\u57fa\u65bc\u6a02\u5929\u91ab\u85e5\u7684Alluminox\u2122<sup>TM<\/sup>\u5e73\u53f0\u958b\u767c\uff0c\u662f\u4e00\u7a2e\u6297\u9ad4-\u67d3\u5291\u8907\u5408\u7269\uff0c\u7531\u91dd\u5c0d\u7d30\u80de\u8868\u9762\u4ecb\u767d\u7d20-2 (IL-2)\u53d7\u9ad4\u03b1\u93c8(CD25)\u7684\u55ae\u682a\u6297\u9ad4\uff0c\u548cIRDye\u00ae700DX\uff08\u4e00\u7a2e\u53ef\u88ab\u5149\u6fc0\u6d3b\u7684\u67d3\u5291\uff09\u6240\u7d44\u6210\u3002RM-1995\u5149\u514d\u75ab\u7642\u6cd5\u7684\u4f5c\u7528\u662f\u7167\u5c04690nm\u975e\u71b1\u7d05\u5149\u5f15\u767c\u816b\u7624\u5167\u90e8CD25<sup>+<\/sup>\u8abf\u7bc0T\u7d30\u80de(Tregs)\u7684\u58de\u6b7b<sup>2<\/sup>\u3002Rakuten Medical\u7684\u81e8\u5e8a\u524d\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0cRM-1995\u5149\u514d\u75ab\u7642\u6cd5\u53ef\u91dd\u5c0d\u6027\u6d88\u6ec5\u816b\u7624\u5167\u90e8Treg\uff0c\u8fc5\u901f\u63d0\u9ad8CD8 T\u7d30\u80de\uff1aTreg \u7684\u6bd4\u4f8b\uff0c\u5f9e\u800c\u6e1b\u8f15\u816b\u7624\u5fae\u74b0\u5883\u4e2dTreg\u7684\u6297\u764c\u514d\u75ab\u53cd\u61c9\u6291\u5236\u80fd\u529b\uff0c\u63d0\u9ad8CD8<sup>+<\/sup>\u6548\u61c9T\u7d30\u80de\u7684\u53cd\u61c9\u3002<\/p>\n<p>\u8cc7\u6599\u4f86\u6e90\u8acb\u53c3\u8003\uff1a<\/p>\n<p>[1]Arce Vargas F, Furness AJS, Solomon I, Joshi K, Mekkaoui L, Lesko MH, et al. Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors. Immunity. 2017;46(4):577-586.<\/p>\n<p><sup>2 <\/sup>Sato, K. et al. Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy. Sci Transl Med 8, 352ra110, doi:10.1126\/scitranslmed.aaf6843 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ASP-1929 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