{"id":7592,"date":"2022-07-28T12:03:47","date_gmt":"2022-07-28T04:03:47","guid":{"rendered":"https:\/\/rakuten-med.com\/tw\/?post_type=press_releases&#038;p=7592"},"modified":"2022-07-28T12:01:48","modified_gmt":"2022-07-28T04:01:48","slug":"%e9%a0%ad%e9%a0%b8%e7%99%8c%e9%a6%96%e9%80%b2%e5%8f%b0%e7%81%a3%e7%94%b7%e6%80%a7%e5%8d%81%e5%a4%a7%e7%99%8c%e5%89%8d%e4%b8%89%ef%bc%81%e4%ba%94%e6%88%90%e6%82%a3%e8%80%85%e6%b2%bb%e7%99%82%e5%be%8c","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/tw\/news\/press-releases\/2022\/07\/28\/7592\/","title":{"rendered":"\u982d\u9838\u764c\u9996\u9032\u53f0\u7063\u7537\u6027\u5341\u5927\u764c\u524d\u4e09\uff01\u4e94\u6210\u60a3\u8005\u6cbb\u7642\u5f8c\u4e09\u5e74\u5167\u5fa9\u767c        \u982d\u9838\u764c\u53cb\u5316\u8eab\u300a\u52c7\u6562\u6a02\u5929\u300bMV\u4e3b\u89d2\u9f4a\u5531\u751f\u547d\u4e4b\u6b4c       \u4e94\u5343\u8077\u68d2\u7403\u8ff7\u633a\u8eab\u61c9\u733f\uff01"},"content":{"rendered":"<div id=\"pl-7592\"  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:\u00a0<a href=\"https:\/\/www.youtube.com\/watch?v=pXJusGU6F2Q\">https:\/\/www.youtube.com\/watch?v=pXJusGU6F2Q<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>_____________________________________________________________________________________________________<\/p>\n<p><strong>\u53c3\u8003\u8cc7\u6599\uff1a<\/strong><\/p>\n<p>[1] \u885b\u751f\u798f\u5229\u90e8109\u5e74\u6b7b\u56e0\u7d71\u8a08\u7d50\u679c\u5206\u6790<\/p>\n<p>[2] A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. Pharmaceutics. 2022 Apr 18;14(4):887. doi:10.3390\/pharmaceutics14040887<\/p>\n<p>[3] Athanassios Argiris,1,2,* Kevin J. Harrington,3. Evidence-Based Treatment Options in Recurrent and\/or Metastatic Squamous Cell Carcinoma of the Head and Neck. Front Oncol. 2017; 7: 72. Published online 2017 May 9.<\/p>\n<p>[4] \u885b\u751f\u798f\u5229\u90e8108\u5e74\u764c\u75c7\u767b\u8a18\u5831\u544a<\/p>\n<p>[5] Daniela Alterio, Giulia Marvaso, Annamaria Ferrari, Stefania Volpe, Roberto Orecchia, Barbara Alicja Jereczek-Fossa (2019). Modern radiotherapy for head and neck cancer<\/p>\n<p>[6] Nerina Denaro, Marco Carlo Merlano and Elvio Grazioso Russi. Follow-up in Head and Neck Cancer: Do More Does It Mean Do Better? A Systematic Review and Our Proposal Based on Our Experience. Clin Exp Otorhinolaryngol 2016 Dec; 9(4): 287\u2013297. doi: 10.21053\/ceo.2015.00976<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u95dc\u65bc\u6a02\u5929\u91ab\u85e5<\/strong><\/p>\n<p>\u6a02\u5929\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8(Rakuten Medical Inc.)\u662f\u4e00\u5bb6\u5168\u7403\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5728 Alluminox\u2122 \u5e73\u53f0\u4e0a\u958b\u767c\u53ca\u5546\u696d\u5316\u7cbe\u6e96\u91dd\u5c0d\u7d30\u80de\u7684\u8a66\u9a57\u6027\u7642\u6cd5\u3002\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5df2\u986f\u793a\u9019\u500b\u5e73\u53f0\u80fd\u8a98\u767c\u5feb\u901f\u53ca\u9078\u64c7\u6027\u7684\u7d30\u80de\u6bba\u50b7\u8207\u816b\u7624\u58de\u6b7b\u3002Alluminox\u7642\u6cd5\u5c1a\u672a\u5728\u65e5\u672c\u4ee5\u5916\u5730\u5340\u7372\u5f97\u4efb\u4f55\u76e3\u7ba1\u6a5f\u69cb\u7684\u5b89\u5168\u6027\u8207\u6709\u6548\u6027\u6838\u51c6\u3002ASP-1929 \u662f\u6a02\u5929\u91ab\u85e5\u5728 Alluminox\u2122 \u5e73\u53f0\u4e0a\u958b\u767c\u7684\u7b2c\u4e00\u7a2e\u8a66\u9a57\u6027\u85e5\u7269\uff0c\u5df2\u7372\u5f97 FDA \u7684\u5feb\u901f\u5be9\u67e5\u8a8d\u5b9a\uff0c\u4ee5\u53ca\u65e5\u672c\u539a\u751f\u52de\u52d5\u7701 ( Japanese Ministry of Health, Labour, and Welfare) \u7684\u5148\u9a45\u7642\u6cd5\u8a8d\u5b9a\uff0c\u76ee\u524d\u6b63\u5728\u5168\u7403\u9032\u884c\u5fa9\u767c\u6027\u982d\u9838\u764c\u7684\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u6a02\u5929\u91ab\u85e5\u4ee5\u6230\u52dd\u764c\u75c7\u70ba\u5df1\u4efb\uff0c\u4ee5\u8fc5\u901f\u53ca\u5b89\u5168\u7684\u65b9\u5f0f\uff0c\u76e1\u53ef\u80fd\u70ba\u5168\u7403\u66f4\u591a\u7684\u60a3\u8005\u63d0\u4f9b\u5275\u65b0\u6cbb\u7642\u3002\u6a02\u5929\u91ab\u85e5\u76ee\u524d\u5728\u5168\u7403\u4e94\u500b\u570b\u5bb6\u8a2d\u6709\u8fa6\u516c\u64da\u9ede\uff0c\u5305\u62ec\u7f8e\u570b\u7e3d\u90e8\u3001\u65e5\u672c\u3001\u8377\u862d\u3001\u53f0\u7063\u8207\u745e\u58eb\u3002\u95dc\u65bc\u66f4\u591a\u8cc7\u8a0a\u8acb\u9020\u8a2a <a href=\"http:\/\/www.rakuten-med.com\">www.rakuten-med.com<\/a>\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u95dc\u65bc<\/strong><strong>Alluminox\u2122<\/strong><strong>\u5e73\u53f0<\/strong><\/p>\n<p>Alluminox\u2122 \u5e73\u53f0\u662f\u4e00\u500b\u8a66\u9a57\u5e73\u53f0\uff0c\u4ee5\u540d\u70ba\u5149\u514d\u75ab\u7642\u6cd5 (photoimmunotherapy) \u7684\u764c\u75c7\u7642\u6cd5\u4f5c\u70ba\u57fa\u790e\uff1b\u5149\u514d\u75ab\u7642\u6cd5\u662f\u7531\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240 (National Cancer Institute) \u7684 Hisataka Kobayashi \u535a\u58eb\u8207\u5718\u968a\u5171\u540c\u958b\u767c\u3002\u6a02\u5929\u91ab\u85e5\u76ee\u524d\u6b63\u5728\u767c\u5c55 Alluminox\u5e73\u53f0\uff0c\u4ee5\u6210\u70ba\u7531\u85e5\u7269\u3001\u91ab\u7642\u5668\u6750\u548c\u5176\u4ed6\u76f8\u95dc\u7d44\u6210\u90e8\u5206\u6240\u69cb\u6210\u7684\u6280\u8853\u3002\u5e73\u53f0\u7684\u85e5\u7269\u90e8\u5206\u662f\u7531\u4e00\u500b\u6a19\u9776\u5206\u5b50\u8207\u4e00\u500b\u6216\u591a\u500b\u67d3\u5291\u63a5\u5408\u6240\u69cb\u6210\uff0c\u9032\u800c\u9054\u5230\u9078\u64c7\u6027\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\u7684\u7d50\u679c\u3002\u91ab\u7642\u5668\u6750\u90e8\u5206\u662f\u7531\u4e00\u500b\u5149\u6e90\u6240\u69cb\u6210\uff0c\u6703\u767c\u6563\u975e\u71b1\u5149\u7dda\u5c40\u90e8\u7167\u5c04\u76ee\u6a19\u7d30\u80de\uff0c\u4ee5\u77ac\u9593\u6d3b\u5316\u85e5\u7269\u3002 \u6839\u64da\u81e8\u5e8a\u524d\u7684\u8cc7\u6599\uff0c\u986f\u793a\u9019\u500b\u6d3b\u5316\u4f5c\u7528\u80fd\u900f\u904e\u751f\u7269\u7269\u7406\u904e\u7a0b\u7834\u58de\u76ee\u6a19\u7d30\u80de\u7684\u7d30\u80de\u819c\u5b8c\u6574\u6027\uff0c\u9032\u800c\u5f15\u8d77\u76ee\u6a19\u7d30\u80de\u7684\u5feb\u901f\u53ca\u9078\u64c7\u6027\u58de\u6b7b\u3002\u5728Alluminox\u5e73\u53f0\u4e0a\u958b\u767c\u7684\u7642\u6cd5\u4e5f\u53ef\u80fd\u6703\u56e0\u70ba\u76ee\u6a19\u7d30\u80de\u7684\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u4ea1\uff0c\u4ee5\u53ca\uff0f\u6216\u6d88\u9664\u5fae\u74b0\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u5143\u7d20\uff0c\u800c\u9020\u6210\u5c40\u90e8\u6027\u53ca\u5168\u8eab\u6027\u7684\u5148\u5929\u8207\u5f8c\u5929\u514d\u75ab\u6d3b\u5316\u4f5c\u7528\u3002Alluminox\u7642\u6cd5\u5c1a\u672a\u5728\u65e5\u672c\u4ee5\u5916\u5730\u5340\u7372\u5f97\u4efb\u4f55\u76e3\u7ba1\u6a5f\u69cb\u7684\u5b89\u5168\u6027\u8207\u6709\u6548\u6027\u6838\u51c6\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u95dc\u65bc<\/strong><strong>ASP-1929<\/strong><\/p>\n<p>\u81ea 2013 \u5e74\u8d77\uff0c\u6a02\u5929\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u4e00\u76f4\u4f7f\u7528\u7368\u5bb6\u6388\u6b0a\u7684\u6297\u9ad4\u8907\u5408\u7269\uff0c\u4ee5Alluminox\u2122 \u6280\u8853\u5e73\u53f0\u4f5c\u70ba\u57fa\u790e\u958b\u767c\u5168\u65b0\u7684\u764c\u75c7\u7642\u6cd5\u3002ASP-1929 \u662f\u6a02\u5929\u91ab\u85e5\u4f7f\u7528 Alluminox \u5e73\u53f0\u958b\u767c\u7522\u54c1\u7dda\u7684\u7b2c\u4e00\u500b\u85e5\u7269\uff0c\u9019\u500b\u6297\u9ad4\u67d3\u5291\u8907\u5408\u9ad4\u662f\u7531\u6297\u9ad4 cetuximab \u53ca\u5149\u6d3b\u5316\u67d3\u5291 IRDye\u00ae 700DX \u6240\u7d44\u6210\u3002ASP-1929 \u7d50\u5408\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08epidermal growth factor receptor\uff0c\u7c21\u7a31 EGFR\uff09\uff0c\u9019\u500b\u764c\u75c7\u6297\u539f\u6703\u8868\u73fe\u5728\u591a\u7a2e\u985e\u578b\u7684\u5be6\u8cea\u56fa\u614b\u7624\u4e2d\uff0c\u5305\u62ec\u982d\u9838\u764c\u3001\u76ae\u819a\u764c\u3001\u98df\u9053\u764c\u3001\u80ba\u764c\u3001\u5927\u8178\u764c\u8207\u80f0\u81df\u764c\u3002ASP-1929 \u5728\u8207\u764c\u7d30\u80de\u7d50\u5408\u5f8c\uff0c\u5c31\u6703\u7531\u96f7\u5c04\u88dd\u7f6e\u7cfb\u7d71\u767c\u5c04\u7684\u975e\u71b1\u6027\u7d05\u5149 (690 nm) \u7167\u5c04\uff0c\u9032\u884c\u5c40\u90e8\u6d3b\u5316\u3002\u6839\u64da\u81e8\u5e8a\u524d\u8cc7\u6599\uff0c\u6307\u51fa Alluminox \u6280\u8853\u80fd\u8a98\u767c\u751f\u7269\u7269\u7406\u904e\u7a0b\uff0c\u4e26\u7834\u58de\u76ee\u6a19\u7d30\u80de\u7684\u7d30\u80de\u819c\u5b8c\u6574\u6027\uff0c\u9054\u5230\u764c\u7d30\u80de\u6b7b\u4ea1\u8207\u816b\u7624\u58de\u6b7b\u7684\u7d50\u679c\u3002ASP-1929 \u5728 2020 \u5e74 9 \u6708\u7372\u5f97\u65e5\u672c\u539a\u751f\u52de\u52d5\u7701\u7684\u6709\u689d\u4ef6\u65e9\u671f\u6838\u51c6\uff0c\u4e14\u76ee\u524d\u6b63\u5728\u5168\u7403\u9032\u884c\u5fa9\u767c\u6027\u982d\u9838\u764c\u7684\u7b2c\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u6a02\u5929\u91ab\u85e5\u751f\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6b63\u900f\u904e\u9032\u884c\u55ae\u4e00\u6cbb\u7642\uff0c\u4ee5\u53ca\u548c\u5176\u4ed6\u85e5\u7269\u4e4b\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u63a8\u52d5\u7522\u54c1\u958b\u767c\u3002ASP-1929 \u8207\u96f7\u5c04\u88dd\u7f6e\u7cfb\u7d71\u5c1a\u672a\u5728\u65e5\u672c\u4ee5\u5916\u5730\u5340\u7372\u5f97\u4efb\u4f55\u76e3\u7ba1\u6a5f\u69cb\u6838\u51c6\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u524d\u77bb\u6027\u8072\u660e<\/strong><\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u5167\u542b\u7684\u524d\u77bb\u6027\u8072\u660e\u7686\u7b26\u5408\uff08\u7f8e\u570b\uff09\u300a1995 \u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u300b\u7684\u5b89\u5168\u6e2f\u689d\u6b3e\u3002\u9019\u4e9b\u8072\u660e\u5305\u542b\u5404\u7a2e\u4e0d\u540c\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u548c\u5047\u8a2d\uff0c\u53ef\u80fd\u81f4\u4f7f\u6a02\u5929\u91ab\u85e5\u7684\u5546\u696d\u8a08\u756b\u8207\u7d50\u679c\u6703\u8207\u8072\u660e\u4e2d\u6240\u8868\u9054\u7684\u9810\u6e2c\u7d50\u679c\u8207\u9810\u671f\u4e0d\u7b26\u3002\u9019\u4e9b\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u7684\u5167\u542b\u8cc7\u8a0a\u662f\u6709\u95dc\u5305\u62ec ASP-1929\u3001Alluminox\u2122 \u5e73\u53f0\u8207 IRDye\u00ae 700Dx \u7b49\u7522\u54c1\u7684\u72c0\u614b\u8207\u958b\u767c\uff0c\u4ee5\u53ca\u5176\u4ed6\u6cd5\u898f\u8207\u884c\u92b7\u6388\u6b0a\u5de5\u4f5c\u3001ASP-1929 \u8207\u5176\u4ed6\u4f7f\u7528 Alluminox \u5e73\u53f0\u5275\u9020\u4e4b\u7642\u6cd5\u7684\u53ef\u80fd\u7642\u6548\u3001\u529f\u6548\u8207\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u516c\u544a\u7533\u5831\u7684\u72c0\u614b\u3002\u7522\u54c1\u672a\u5fc5\u80fd\u53d6\u5f97\u6838\u51c6\u53ca\u5728\u5546\u696d\u4e0a\u7372\u5229\u3002\u524d\u77bb\u6027\u8072\u660e\u662f\u76f8\u95dc\u65bc ASP-1929 \u7684\u53ef\u80fd\u7642\u6548\u3001\u529f\u6548\u53ca\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u516c\u544a\u7533\u5831\u7684\u72c0\u614b\u3002\u9019\u985e\u8072\u660e\u53ef\u80fd\u5305\u542b\u5982\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u5e0c\u671b\u300d\u3001\u300c\u9810\u4f30\u300d\u3001\u300c\u770b\u4f3c\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u4f01\u5716\u300d\u3001\u300c\u53ef\u80fd\u300d\u3001\u300c\u5efa\u8b70\u300d\u3001\u300c\u8a08\u5283\u300d\u3001\u300c\u7b56\u7565\u300d\u3001\u300c\u5373\u5c07\u300d\u8207\u300c\u78ba\u5be6\u300d\u7b49\u7528\u8a5e\uff0c\u4e26\u6703\u4ee5\u6211\u5011\u7684\u7576\u524d\u4fe1\u5ff5\u70ba\u4f9d\u64da\u3002\u6b64\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u6703\u4f7f\u7528\u5982\u300c\u91cd\u8981\u300d\u3001\u300c\u986f\u8457\u300d\u8207\u300c\u7570\u5e38\u300d\u7b49\u7528\u8a5e\uff0c\u8868\u9054\u95dc\u65bc\u81e8\u5e8a\u8a66\u9a57\u8cc7\u6599\u7684\u610f\u898b\u9673\u8ff0\u3002\u9032\u884c\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u5305\u542b\u5404\u7a2e\u98a8\u96aa\u8207\u4e0d\u78ba\u5b9a\u6027\uff0c\u7279\u5225\u662f\u5728 ASP-1929 \u88fd\u9020\u904e\u7a0b\u4e2d\u5f62\u6210\u7684\u554f\u984c\u3001\u767c\u751f\u4e0d\u826f\u5b89\u5168\u4e8b\u4ef6\u3001\u7121\u6cd5\u5c55\u793a\u7642\u6548\u7684\u60c5\u6cc1\uff0c\u4ee5\u53ca\u5176\u4ed6\u5404\u7a2e\u5408\u7406\u53ca\u4e0d\u5408\u7406\u7684\u98a8\u96aa\u8207\u4e0d\u78ba\u5b9a\u6027\u3002\u57fa\u65bc\u9019\u500b\u539f\u56e0\uff0c\u5305\u62ec ASP-1929 \u5728\u5546\u696d\u5316\u904e\u7a0b\u4e2d\u7684\u6cd5\u898f\u6838\u51c6\u53ca\u4e0d\u78ba\u5b9a\u6027\u7b49\u5be6\u969b\u7d50\u679c\uff0c\u53ef\u80fd\u6703\u548c\u767c\u5e03\u8cc7\u8a0a\u4e0d\u7b26\u3002\u9664\u9069\u7528\u6cd5\u5f8b\u7684\u8981\u6c42\u7bc4\u570d\uff0c\u7121\u8ad6\u662f\u56e0\u70ba\u65b0\u8cc7\u8a0a\u3001\u672a\u4f86\u7684\u767c\u5c55<\/p>\n<p>\u6216\u4e8b\u4ef6\u3001\u5047\u8a2d\u51fa\u73fe\u8b8a\u5316\u3001\u5f71\u97ff\u524d\u77bb\u6027\u8072\u660e\u7684\u56e0\u7d20\u51fa\u73fe\u8b8a\u5316\uff0c\u6a02\u5929\u91ab\u85e5\u7686\u4e0d\u627f\u64d4\u516c\u958b\u66f4\u65b0\u672c\u524d\u77bb\u6027\u8072\u660e\u6216\u5176\u4ed6\u524d\u77bb\u6027\u8072\u660e\u7684\u7fa9\u52d9\u3002\u82e5\u6709\u4e00\u500b\u6216\u591a\u500b\u524d\u77bb\u6027\u8072\u660e\u66f4\u65b0\uff0c\u4e0d\u5f97\u63a8\u65b7\u6210\u9019\u4e9b\u6216\u5176\u4ed6\u524d\u77bb\u6027\u8072\u660e\u4e5f\u6703\u9032\u884c\u984d\u5916\u7684\u66f4\u65b0\u3002<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-7592-0-0-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"1\" ><div class=\"panel-widget-style panel-widget-style-for-7592-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-button so-widget-sow-button-flat-ebadb818959c-7592\"\n\t\t\t\n\t\t><div class=\"ow-button-base ow-button-align-center\"\n>\n\t\t\t<a\n\t\t\t\t\thref=\"https:\/\/rakuten-med.com\/us\/contact\/media\/\"\n\t\t\t\t\tclass=\"rak-btn sowb-button ow-icon-placement-left ow-button-hover\" \t>\n\t\t<span>\n\t\t\t\n\t\t\tContact 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