{"id":7618,"date":"2023-08-03T12:02:25","date_gmt":"2023-08-03T04:02:25","guid":{"rendered":"https:\/\/rakuten-med.com\/tw\/?post_type=press_releases&p=7618"},"modified":"2023-08-03T12:02:25","modified_gmt":"2023-08-03T04:02:25","slug":"%e6%a8%82%e5%a4%a9%e9%86%ab%e8%97%a5-%e5%9c%a8%e6%97%a5%e6%9c%ac%e9%96%8b%e5%b1%95anti-cd25-%e6%8a%97%e9%ab%94%e6%9f%93%e5%8a%91%e8%a4%87%e5%90%88%e9%ab%94-rm-1995%e5%85%89%e5%85%8d%e7%96%ab%e7%99%82","status":"publish","type":"press_releases","link":"https:\/\/rakuten-med.com\/tw\/news\/press-releases\/2023\/08\/03\/7618\/","title":{"rendered":"\u6a02\u5929\u91ab\u85e5 \u5728\u65e5\u672c\u958b\u5c55anti-CD25 \u6297\u9ad4\u67d3\u5291\u8907\u5408\u9ad4 RM-1995\u5149\u514d\u75ab\u7642\u6cd5I \u671f\u8a66\u9a57\u6cbb\u7642\u4f34\u6709\u809d\u8f49\u79fb\u7684\u665a\u671f\u6216\u8907\u767c\u6027\u5be6\u9ad4\u7624"},"content":{"rendered":"

[<\/span><\/span>\u52a0\u5dde\u8056\u5730\u7259\u54e5\u8a0a<\/span><\/span><\/span><\/span>]-<\/span><\/span>\u6a02\u5929\u91ab\u85e5\u5ba3\u4f48\u5728\u65e5\u672c\u958b\u59cb\u958b\u5c55 <\/span><\/span><\/span><\/span>Alluminox\u2122 <\/span><\/span>\u6cbb\u7642\uff08\u5149\u514d\u75ab\u7642\u6cd5\uff09\u7684 <\/span><\/span><\/span><\/span>1 <\/span><\/span>\u671f\u958b\u653e\u6a19\u7c64\u5291\u91cf\u4e0a\u5347\u81e8\u5e8a\u8a66\u9a57\uff08<\/span><\/span><\/span><\/span>RM-1995-102<\/span><\/span>\uff1b<\/span><\/span><\/span><\/span>jRCT <\/span><\/span><\/u><\/span>\u7de8\u865f\uff1a<\/span><\/span><\/u><\/span>2031220721<\/span><\/span><\/a>\uff09\uff0c\u8a72\u8a66\u9a57\u5229\u7528\u65b0\u958b\u767c\u7684\u6297<\/span><\/span><\/span><\/span>CD25 <\/span><\/span>\u6297\u9ad4\u67d3\u5291\u8907\u5408\u9ad4<\/span><\/span><\/span><\/span>(RM-1995) <\/span><\/span>\u548c\u6ce2\u9577 <\/span><\/span><\/span><\/span>690 nm <\/span><\/span>\u7684\u96f7\u5c04\u5149\u7167\u88dd\u7f6e\u3002\u8a72\u8a66\u9a57\u7642\u6cd5\u662f\u91dd\u5c0d\u60a3\u6709\u809d\u8f49\u79fb\u7684\u665a\u671f\u6216\u5fa9\u767c\u6027\u5be6\u9ad4\u7624\u60a3\u8005\u3002<\/span><\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u9019\u662f\u4e00\u9805 <\/span><\/span><\/span><\/span>1 <\/span><\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5c0d\u50cf\u662f\u60a3\u6709\u665a\u671f\u6216\u5fa9\u767c\u6027\u5be6\u9ad4\u7624\uff0c\u75c5\u60a3\u81f3\u5c11\u9700\u6709\u4e00\u500b\u53ef\u4ee5\u88ab\u96f7\u5c04\u5149\u7167\u5c04\u7684\u8f49\u79fb\u6027\u809d\u75c5\u7076\u4e14\u6c92\u6709\u6a19\u6e96\u6cbb\u7642\u65b9\u6cd5\u7684\u60a3\u8005\u3002\u8a72\u7814\u7a76\u5c07\u8a55\u4f30\u8a72\u85e5\u54c1\u4f5c\u70ba\u55ae\u4e00\u7642\u6cd5\uff08<\/span><\/span><\/span><\/span>1a <\/span><\/span>\u671f\u548c <\/span><\/span><\/span><\/span>1b <\/span><\/span>\u671f\uff09\u4ee5\u53ca\u8207<\/span><\/span><\/span><\/span>pembrolizumab<\/span><\/span>\uff08<\/span><\/span><\/span><\/span>1c <\/span><\/span>\u671f\uff09\u806f\u5408\u6cbb\u7642\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4ee5\u78ba\u5b9a\u6700\u5927\u8010\u53d7\u5291\u91cf\uff08<\/span><\/span><\/span><\/span>MTD<\/span><\/span>\uff09\u6216\u6700\u5927\u63a5\u53d7\u5291\u91cf\uff08<\/span><\/span><\/span><\/span>MAD<\/span><\/span>\uff09\u4ee5\u53ca<\/span><\/span><\/span><\/span>2 <\/span><\/span>\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u4f7f\u7528\u7684\u5efa\u8b70\u5291\u91cf\u3002\u6b64\u5916\uff0c\u6b64\u8a66\u9a57\u9084\u5c07\u8a55\u4f30<\/span><\/span><\/span><\/span>Alluminox\u2122 <\/span><\/span>\u91ab\u7642\u5668\u6750\u7528\u65bc\u809d\u8f49\u79fb\u7684\u5b89\u5168\u6027<\/span><\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u809d\u8f49\u79fb\u7684<\/span><\/span><\/span>\u539f\u767c<\/span><\/span><\/span><\/span>\u90e8\u4f4d\u5305\u62ec\u6d88\u5316\u7cfb\u7d71\u816b\u7624\uff0c\u4f8b\u5982<\/span><\/span><\/span>\u5927\u8178<\/span><\/span><\/span><\/span>\u76f4\u8178\u764c\u3001\u80c3\u764c\u548c\u80f0<\/span><\/span><\/span>\u81df<\/span><\/span><\/span><\/span>\u764c\uff0c\u4ee5\u53ca\u4e73\u764c\u548c\u80ba\u764c\u3002\u809d\u81df\u662f\u591a\u7a2e\u764c\u75c7\u7684\u5e38\u898b\u8f49\u79fb\u5668\u5b98<\/span><\/span><\/span><\/span>1<\/span><\/span><\/sup><\/span>\uff0c\u9019\u4e9b\u8f49\u79fb\u75c5\u7076\u8207\u4e0d\u826f\u9810\u5f8c\u76f8\u95dc<\/span><\/span><\/span><\/span>2<\/span><\/span><\/sup><\/span>\u3002<\/span><\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u6a02\u5929\u91ab\u85e5\u5171\u540c\u57f7\u884c\u9577\u4e09\u6728\u8c37\u6d69\u53f2 \u8868\u793a\uff1a\u201c\u6211\u5011\u5f88\u9ad8\u8208\u5728\u65e5\u672c\u5c55\u958b\u7b2c\u4e8c\u7a2e\u65b0\u958b\u767c\u85e5\u7269 <\/span><\/span><\/span>RM-1995 <\/span><\/span>\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u809d\u8f49\u79fb\u662f\u591a\u7a2e\u764c\u75c7\u7684\u5e38\u898b\u73fe\u8c61\uff0c\u76ee\u524d\u6cbb\u7642<\/span><\/span>\u7684<\/span><\/span><\/span><\/span>\u6548\u679c\u6709\u9650\u3002\u6211\u5011\u5805\u4fe1\uff0c\u9019\u7a2e\u6cbb\u7642\u6709\u53ef\u80fd\u6210\u70ba\u7b49\u5f85\u65b0\u7642\u6cd5\u7684\u60a3<\/span><\/span><\/span>\u200b\u200b<\/span><\/span><\/span><\/span>\u8005\u7684\u5e0c\u671b\u71c8\u5854\u3002\u5341\u5e74\u524d\uff0c\u6211\u7236\u89aa\u7684\u80f0<\/span><\/span><\/span>\u81df<\/span><\/span><\/span><\/span>\u764c\u6210\u70ba\u6211\u53c3\u8207\u958b\u767c\u6a02\u5929\u91ab\u85e5<\/span><\/span><\/span><\/span>Alluminox <\/span><\/span>\u5149\u514d\u75ab\u7642\u6cd5\u7684\u50ac\u5316\u5291\u3002\u6211\u8a8d\u70ba\u6211\u5011\u5728\u7814\u7a76\u6cbb\u7642\u591a\u7a2e\u764c\u75c7\uff08\u5305\u62ec\u80f0<\/span><\/span><\/span>\u81df<\/span><\/span><\/span>\u764c\uff09\u7684\u6cbb\u7642\u65b9\u6cd5\u65b9\u9762\u9081\u51fa\u4e86\u91cd\u8981\u4e00\u6b65\u3002<\/span><\/span><\/span><\/p>\n

2021<\/span><\/span>\u5e74<\/span><\/span><\/span>11<\/span><\/span>\u6708\uff0c\u9019\u9805\u201c\u4f7f\u7528<\/span><\/span><\/span><\/span>anti-<\/span><\/span><\/span>CD25<\/span><\/span>\u6297\u9ad4\u67d3\u5291\u8907\u5408\u9ad4\u91dd\u5c0d\u8abf\u7bc0\u6027<\/span><\/span><\/span>T<\/span><\/span>\u7d30\u80de\u7684\u5275\u65b0\u764c\u75c7\u7642\u6cd5\uff08<\/span><\/span><\/span>RM-1995<\/span><\/span>\uff09\u201d<\/span><\/span><\/span>\u7684\u7814\u7a76<\/span><\/span><\/span>\u88ab\u65e5\u672c\u91ab\u5b78\u7814\u7a76\u8207\u767c\u5c55\u6a5f\u69cb\uff08<\/span><\/span><\/span>AMED<\/span><\/span>\uff09\u9078\u4e2d\u3002\u9019\u9805\u7814\u7a76\u662f\u5728 <\/span><\/span><\/span>AMED <\/span><\/span>\u7684\u652f\u6301\u4e0b\u9032\u884c\u7684<\/span><\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u95dc\u65bc\u6a02\u5929\u91ab\u85e5<\/span><\/u><\/span><\/b><\/span><\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u6a02\u5929\u91ab\u85e5<\/span><\/span><\/span>(Rakuten Medical Inc.)<\/span><\/span><\/span>\u662f\u4e00\u5bb6\u5168\u7403\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5728 <\/span><\/span>Alluminox\u2122 <\/span><\/span><\/span>\u5e73\u53f0\u4e0a\u958b\u767c\u53ca\u5546\u696d\u5316\u7cbe\u6e96\u91dd\u5c0d\u7d30\u80de\u7684\u8a66\u9a57\u6027\u7642\u6cd5\u3002\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5df2\u986f\u793a\u9019\u500b\u5e73\u53f0\u80fd\u8a98\u767c\u5feb\u901f\u53ca\u9078\u64c7\u6027\u7684\u7d30\u80de\u6bba\u50b7\u8207\u816b\u7624\u58de\u6b7b\u3002<\/span><\/span>Alluminox <\/span><\/span><\/span>\u7642\u6cd5\u5c1a\u672a\u5728\u65e5\u672c\u4ee5\u5916\u5730\u5340\u7372\u5f97\u4efb\u4f55\u76e3\u7ba1\u6a5f\u69cb\u7684\u5b89\u5168\u6027\u8207\u6709\u6548\u6027\u6838\u51c6\u3002\u6a02\u5929\u91ab\u85e5\u4ee5\u6230\u52dd\u764c\u75c7\u70ba\u5df1\u4efb\uff0c\u4ee5\u8fc5\u901f\u53ca\u5b89\u5168\u7684\u65b9\u5f0f\uff0c\u76e1\u53ef\u80fd\u70ba\u5168\u7403\u66f4\u591a\u7684\u60a3\u8005\u63d0\u4f9b\u5275\u65b0\u6cbb\u7642\u3002\u6a02\u5929\u91ab\u85e5\u76ee\u524d\u5728\u5168\u7403\u516d\u500b\u570b\u5bb6\u8a2d\u6709\u8fa6\u516c\u64da\u9ede\uff0c\u5305\u62ec\u7f8e\u570b\u7e3d\u90e8\u3001\u65e5\u672c\u3001\u53f0\u7063\u3001\u8377\u862d\u3001\u8207\u745e\u58eb\u3001\u5370\u5ea6\u3002\u95dc\u65bc\u66f4\u591a\u8cc7\u8a0a\u8acb\u9020\u8a2a\u00a0<\/span><\/span><\/span>www.rakuten-med.com<\/span><\/span><\/span><\/a><\/u><\/span><\/span>\u3002<\/span><\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u95dc\u65bc<\/span><\/span><\/span><\/b>RM-1995<\/span><\/b>
\n<\/span><\/b><\/u><\/span>RM-1995 <\/span><\/span>\u662f\u6a02\u5929\u91ab\u85e5\u4f7f\u7528 <\/span><\/span><\/span><\/span>Alluminox <\/span><\/span>\u5e73\u53f0\u958b\u767c\u7684\u6297\u9ad4\u67d3\u5291\u8907\u5408\u9ad4\u3002\u7531\u5c08\u9580\u91dd\u5c0d\u7d30\u80de\u8868\u9762\u754c\u767d\u7d20<\/span><\/span><\/span><\/span>2(IL-2)<\/span><\/span>\u53d7\u9ad4<\/span><\/span><\/span><\/span>\u03b1<\/span><\/span>\u934a<\/span><\/span><\/span><\/span>(CD25)<\/span><\/span>\u7684\u55ae\u682a\u6297\u9ad4\u4ee5\u53ca\u5149\u6d3b\u5316\u67d3\u5291 <\/span><\/span><\/span><\/span>IRDye\u00ae 700DX <\/span><\/span>\u6240\u7d44\u6210\u3002<\/span><\/span><\/span><\/span>RM-1995<\/span><\/span>\u5149\u514d\u75ab\u7642\u6cd5\u7684\u8a2d\u8a08\u662f\u5728\u53d7\u5230<\/span><\/span><\/span><\/span>690 nm<\/span><\/span><\/span>\u975e\u71b1\u6027\u7d05\u5149<\/span><\/span><\/span>\u7167\u5c04\u5f8c\uff0c\u80fd\u660e\u78ba\u6bba\u6b7b\u816b\u7624\u5167\u90e8\u7684<\/span><\/span><\/span><\/span><\/span>Treg<\/span><\/span>\uff0c\u9032\u800c\u6e1b\u8f15\u816b\u7624\u70ba\u74b0\u5883\u4e2d\u7684<\/span><\/span><\/span><\/span>Treg<\/span><\/span>\u4ecb\u5165\u6291\u5236\u4f5c\u7528\uff0c\u4e26\u8fc5\u901f\u63d0\u9ad8<\/span><\/span><\/span><\/span>CD8 T<\/span><\/span>\u7d30\u80de\u5c0d<\/span><\/span><\/span><\/span>Treg<\/span><\/span>\u7684\u6bd4\u4f8b\uff0c\u4ee5\u53ca\u5728\u63d0\u5347\u6548\u61c9<\/span><\/span><\/span><\/span>CD8<\/span><\/span><\/span>+ <\/span><\/span><\/sup><\/span>T<\/span><\/span>\u7d30\u80de\u53cd\u61c9\u7684\u6d3b\u6027\u3002<\/span><\/span><\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u95dc\u65bc<\/span><\/span><\/b>Alluminox\u2122 <\/span><\/b>\u5e73\u53f0<\/b><\/span>
\n<\/span><\/b><\/u><\/span>Alluminox\u2122 <\/span>\u5e73\u53f0\u662f\u4e00\u500b\u8a66\u9a57\u5e73\u53f0\uff0c\u4ee5\u540d\u70ba\u5149\u514d\u75ab\u7642\u6cd5 <\/span>(photoimmunotherapy) <\/span>\u7684\u764c\u75c7\u7642\u6cd5\u4f5c\u70ba\u57fa\u790e<\/span>;<\/span>\u5149\u514d\u75ab\u7642\u6cd5\u662f\u7531\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240 <\/span>(National Cancer Institute) <\/span>\u7684\u5c0f\u6797\u4e45\u9686\u535a\u58eb\u8207\u5718\u968a\u5171\u540c\u958b\u767c\u3002<\/span>\u6a02\u5929\u91ab\u85e5\u76ee\u524d\u6b63\u5728\u767c\u5c55 <\/span><\/span>Alluminox <\/span>\u5e73\u53f0\uff0c\u4ee5\u6210\u70ba\u7531\u85e5<\/span><\/span>\u54c1<\/span><\/span>\u3001\u91ab\u7642\u5668\u6750\u548c\u5176\u4ed6\u76f8\u95dc\u7d44\u6210\u90e8\u5206\u6240\u69cb\u6210\u7684\u6280\u8853\u3002\u5e73\u53f0\u7684\u85e5<\/span>\u54c1<\/span><\/span>\u90e8\u5206\u662f\u7531\u4e00\u500b\u6a19\u9776\u5206\u5b50\u8207\u4e00\u500b\u6216\u591a\u500b\u67d3\u5291\u63a5\u5408\u6240\u69cb\u6210\uff0c\u9032\u800c\u9054\u5230\u9078\u64c7\u6027\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u7d50\u5408\u7684\u7d50\u679c\u3002\u91ab\u7642\u5668\u6750\u90e8\u5206\u662f\u7531\u4e00\u500b\u5149\u6e90\u6240\u69cb\u6210\uff0c\u6703<\/span>\u5c40<\/span><\/span>\u90e8\u7167\u5c04\u76ee\u6a19\u7d30\u80de\uff0c\u4ee5\u77ac\u9593\u6d3b\u5316\u85e5\u7269\u3002 \u6839\u64da\u81e8\u5e8a\u524d\u7684\u8cc7\u6599\uff0c\u986f\u793a\u9019\u500b\u6d3b\u5316\u4f5c\u7528\u80fd\u900f\u904e\u751f\u7269\u7269\u7406\u904e\u7a0b\u7834\u58de\u76ee\u6a19\u7d30\u80de\u7684\u7d30\u80de\u819c\u5b8c\u6574\u6027\uff0c\u9032\u800c\u5f15\u8d77\u76ee\u6a19\u7d30\u80de\u7684\u5feb\u901f\u53ca\u9078\u64c7\u6027\u58de\u6b7b\u3002\u5728 <\/span><\/span>Alluminox <\/span>\u5e73\u53f0\u4e0a\u958b\u767c\u7684\u7642\u6cd5\u4e5f\u53ef\u80fd\u6703\u56e0\u70ba\u76ee\u6a19\u7d30\u80de\u7684\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u4ea1\uff0c\u4ee5\u53ca\uff0f\u6216\u6d88\u9664\u5fae\u74b0\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u5143\u7d20\uff0c\u800c\u9020\u6210\u5c40\u90e8\u6027\u53ca\u5168\u8eab\u6027\u7684\u5148\u5929\u8207\u5f8c\u5929\u514d\u75ab\u6d3b\u5316\u4f5c\u7528\u3002<\/span><\/span>Alluminox <\/span>\u5c1a\u672a\u5728\u65e5\u672c\u4ee5\u5916\u5730\u5340\u7372\u5f97\u4efb\u4f55\u76e3\u7ba1\u6a5f\u69cb\u7684\u5b89\u5168\u6027\u8207\u6709\u6548\u6027\u6838\u51c6\u3002<\/span><\/span><\/span><\/p>\n

 <\/p>\n

\u524d\u77bb\u6027\u8072\u660e<\/span><\/span>
\n<\/span>\u672c\u65b0\u805e\u7a3f\u5167\u542b\u7684\u524d\u77bb\u6027\u8072\u660e\u7686\u7b26\u5408\uff08\u7f8e\u570b\uff09\u300a<\/span>1995 <\/span>\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u300b\u7684\u5b89\u5168\u6e2f\u689d\u6b3e\u3002\u9019\u4e9b\u8072\u660e\u5305\u542b\u5404\u7a2e\u4e0d\u540c\u98a8\u96aa\u3001\u4e0d\u78ba\u5b9a\u6027\u548c\u5047\u8a2d\uff0c\u53ef\u80fd\u81f4\u4f7f\u6a02\u5929\u91ab\u85e5\u7684\u5546\u696d\u8a08\u756b\u8207\u7d50\u679c\u6703\u8207\u8072\u660e\u4e2d\u6240\u8868\u9054\u7684\u9810\u6e2c\u7d50\u679c\u8207\u9810\u671f\u4e0d\u7b26\u3002\u9019\u4e9b\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u7684\u5167\u542b\u8cc7\u8a0a\u662f\u6709\u95dc\u5305\u62ec <\/span>RM-1995<\/span>\u3001<\/span>Alluminox\u2122 <\/span>\u5e73\u53f0\u8207 <\/span>IRDye\u00ae 700Dx <\/span>\u7b49\u7522\u54c1\u7684\u72c0\u614b\u8207\u958b\u767c\uff0c\u4ee5\u53ca\u5176\u4ed6\u6cd5\u898f\u8207\u884c\u92b7\u6388\u6b0a\u5de5\u4f5c\u3001<\/span>RM-1995 <\/span>\u8207\u5176\u4ed6\u4f7f\u7528 <\/span>Alluminox <\/span>\u5e73\u53f0\u5275\u9020\u4e4b\u7642\u6cd5\u7684\u53ef\u80fd\u7642\u6548\u3001\u529f\u6548\u8207\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u516c\u544a\u7533\u5831\u7684\u72c0\u614b\u3002\u7522\u54c1\u672a\u5fc5\u80fd\u53d6\u5f97\u6838\u51c6\u53ca\u5728\u5546\u696d\u4e0a\u7372\u5229\u3002\u524d\u77bb\u6027\u8072\u660e\u662f\u76f8\u95dc\u65bc<\/span>RM-1995<\/span>\u7684\u53ef\u80fd\u7642\u6548\u3001\u529f\u6548\u53ca\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u516c\u544a\u7533\u5831\u7684\u72c0\u614b\u3002\u9019\u985e\u8072\u660e\u53ef\u80fd\u5305\u542b\u5982\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u5e0c\u671b\u300d\u3001\u300c\u9810\u4f30\u300d\u3001\u300c\u770b\u4f3c\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u4f01\u5716\u300d\u3001\u300c\u53ef\u80fd\u300d\u3001\u300c\u5efa\u8b70\u300d\u3001\u300c\u8a08\u5283\u300d\u3001\u300c\u7b56\u7565\u300d\u3001\u300c\u5373\u5c07\u300d\u8207\u300c\u78ba\u5be6\u300d\u7b49\u7528\u8a5e\uff0c\u4e26\u6703\u4ee5\u6211\u5011\u7684\u7576\u524d\u4fe1\u5ff5\u70ba\u4f9d\u64da\u3002 \u6b64\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u6703\u4f7f\u7528\u5982\u300c\u91cd\u8981\u300d\u3001\u300c\u986f\u8457\u300d\u8207\u300c\u7570\u5e38\u300d\u7b49\u7528\u8a5e\uff0c\u8868\u9054\u95dc\u65bc\u81e8\u5e8a\u8a66\u9a57\u8cc7\u6599\u7684\u610f\u898b\u9673\u8ff0\u3002\u9032\u884c\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u5305\u542b\u5404\u7a2e\u98a8\u96aa\u8207\u4e0d\u78ba\u5b9a\u6027\uff0c\u7279\u5225\u662f\u5728<\/span>RM-1995<\/span>\u88fd\u9020\u904e\u7a0b\u4e2d\u5f62\u6210\u7684\u554f\u984c\u3001\u767c\u751f\u4e0d\u826f\u5b89\u5168\u4e8b\u4ef6\u3001\u7121\u6cd5\u5c55\u793a\u7642\u6548\u7684\u60c5\u6cc1\uff0c\u4ee5\u53ca\u5176\u4ed6\u5404\u7a2e\u5408\u7406\u53ca\u4e0d\u5408\u7406\u7684\u98a8\u96aa\u8207\u4e0d\u78ba\u5b9a\u6027\u3002\u57fa\u65bc\u9019\u500b\u539f\u56e0\uff0c\u5305\u62ec <\/span>RM-1995<\/span>\u5728\u5546\u696d\u5316\u904e\u7a0b\u4e2d\u7684\u6cd5\u898f\u6838\u51c6\u53ca\u4e0d\u78ba\u5b9a\u6027\u7b49\u5be6\u969b\u7d50\u679c\uff0c\u53ef\u80fd\u6703\u548c\u767c\u5e03\u8cc7\u8a0a\u4e0d\u7b26\u3002\u9664\u9069\u7528\u6cd5\u5f8b\u7684\u8981\u6c42\u7bc4\u570d\uff0c\u7121\u8ad6\u662f\u56e0\u70ba\u65b0\u8cc7\u8a0a\u3001\u672a\u4f86\u7684\u767c\u5c55\u6216\u4e8b\u4ef6\u3001\u5047\u8a2d\u51fa\u73fe\u8b8a\u5316\u3001\u5f71\u97ff\u524d\u77bb\u6027\u8072\u660e\u7684\u56e0\u7d20\u51fa\u73fe\u8b8a\u5316\uff0c\u6a02\u5929\u91ab\u85e5\u7686\u4e0d\u627f\u64d4\u516c\u958b\u66f4\u65b0\u672c\u524d\u77bb\u6027\u8072\u660e\u6216\u5176\u4ed6\u524d\u77bb\u6027\u8072\u660e\u7684\u7fa9\u52d9\u3002\u82e5\u6709\u4e00\u500b\u6216\u591a\u500b\u524d\u77bb\u6027\u8072\u660e\u66f4\u65b0\uff0c\u4e0d\u5f97\u63a8\u65b7\u6210\u9019\u4e9b\u6216\u5176\u4ed6\u524d\u77bb\u6027\u8072\u660e\u4e5f\u6703\u9032\u884c\u984d\u5916\u7684\u66f4\u65b0\u3002<\/span><\/span><\/p>\n

 <\/p>\n

References:<\/b><\/span><\/span><\/span><\/span><\/p>\n

1. Danielle T<\/span><\/span>. Metastatic Liver Cancer; <\/span><\/span><\/span>MSD Manual Professional Edition<\/span><\/span><\/a><\/u><\/span> (Accessed on July 26, 2023)<\/span><\/span><\/p>\n

2. Yamamoto M. Clinical practice guidelines for the management of liver metastases from extrahepatic primary cancers 2021. J Hepatobiliary Pancreat Sci., 28, 1-25.<\/span><\/span><\/span><\/p>\n

3. <\/span><\/span><\/span>Sato, K. et al. Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy. Sci Transl Med 8, 352ra110, doi:10.1126\/scitranslmed.aaf6843 (2016).<\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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